Hypothalamus and Limbic System - UBC Neuroanatomy - Season 1 - Ep 4
Neuroanatomy
Dr. Claudia Krebs, Tamara Bodnar, Parker Holman, Dr. Joanne Weinberg
UBC Medicine - Educational Media published via YouTube.com
Creative Commons License
Tutorial
Clinical Procedures for Safer Patient Care
Health, Medical
This peer reviewed e-book is a must-read for nurses and other health professionals who strive to teach with creativity and excellence in clinical settings. Each chapter presents current evidence informed educational practice knowledge. Each topic is also presented with text boxes describing ‘Creative Strategies’ that clinical teachers from across Canada have successfully implemented. For those who are interested in background knowledge, the authors provided a comprehensive literature base. And, for those interested mainly in 'what to do,' the text box summaries offer step-by-step directions for creative, challenging activities that both new and experienced instructors can begin using immediately.
Sherri Melrose PhD, RN,et al
British Columbia Institute of Technology (BCIT)
Textbook
Coming Off Psychiatric Drugs: A Harm Reduction Approach to Medication Withdrawal | Will Hall
Psychiatric Drugs
Psychiatric medications can sometimes be very useful, but there is often little information or guidance when the risks and harm start to outweigh the benefits. Will Hall provides an introductory overview of how to come off psychiatric medication. Will Hall is a survivor of a schizophrenia diagnosis who today works as a therapist and teaches internationally on mental diversity, including psychiatric medication. This video provides some basic guidance for anyone considering reducing or coming off psychiatric medications and their supporters, and is discussed in greater detail in the Harm Reduction Guideto Coming Off Psychiatric Drugs.
Will Hall published via YouTube.com
Pathology
Health
In this book we have set out to provide a practical guide to bone marrow diagnosis, based on an integrated assessment of peripheral blood and bone marrow aspirate films, trephine biopsy sections and various supplementary investigations. We believe that a trephine biopsy specimen should not be examined and interpreted in isolation. We have therefore discussed the clinical context of bone marrow diagnosis and have given equal weight to cytological and histological features. Since bone marrow diagnosis is no longer based on morphological features alone we have also, in this edition, discussed in considerable detail the role of immunophenotypic, cytogenetic and molecular genetic analysis.
Barbara J. Bain
David M. Clark
Irvin A. Lampert
Bridget S. Wilkins
Blackwell Science
Textbooks
Kansas State University Human Nutrition Flexbook
Human Nutrition
The CK-12 foundation defines a flexbook as a “free and open source textbook platform where one can build and edit collaborative textbooks1 .” The FNDH 400 (formerly HN 400, department changed its name from Human Nutrition to Food, Nutrition, Dietetics and Health) Flexbook fits this definition, but I felt the name was particularly accurate due to the flexibility of Google Docs that it was built on. The flexbook is divided into 13 chapters with sections and subsections. These are numbered in such a way that the first number represents the chapter. A period separates the chapter from the section number, and another period is followed by the subsection number. The figures are non-copyrighted figures or I have made them myself in PowerPoint. The flexbook also contains links to articles, videos, and animations in Web Link boxes. These can be clicked to open the link, and urls for these resources are also provided at the end of the section or subsection.
Brian Lindshield
Human Anatomy and Physiology Preparatory Course
Human Anatomy
Physiology
The overall purpose of this preparatory course textbook is to help students familiarize with some terms and some basic concepts they will find later in the Human Anatomy and Physiology I course. The organization and functioning of the human organism generally is discussed in terms of different levels of increasing complexity, from the smallest building blocks to the entire body. This Anatomy and Physiology preparatory course covers the foundations on the chemical level, and a basic introduction to cellular level, organ level, and organ system levels. There is also an introduction to homeostasis at the beginning.
Carlos Liachovitzky
CUNY Academic Works
Anatomy and Physiology
The manual contains the following labs: Introduction Tissues Integument Introduction to the Skeleton Axial Skeleton: Skull Axial Skeleton: Vertebral Appendicular Skeleton: Introduction and Pectoral Girdle Appendicular Skeleton: Upper Limbs Appendicular Skeleton: Pelvis Appendicular Skeleton: Lower Limbs Articulations/Joints Body Movements Muscles: Head, Neck, and Back Muscles: Abdomen and Thorax Muscles: Upper Limbs Muscles: Lower Limbs Spinal Cord Brain Cranial Nerves Special Senses: Ear Special Senses: Eye
DeLoris Hesse
Deanna Cozart
Brett Szymik
Rob Nichols
University System of Georgia
tooth
This video shows the first stage of the production of a cast gold crown for a damaged tooth. The crown is made on the model (See Videos 2 and 3) using wax, which will be replaced by molten gold in the lost wax casting process. The technique of making the wax template and adjusting it to fit the model accurately is shown. Courtesy of Dr Christopher Stokes and Dr Duncan Wood
Dr Christopher Stokes and Dr Duncan Wood
School of Clinical Dentistry, The University of Sheffield.
Creative Commons
This video shows the second stage of the production of a cast gold crown for a damaged tooth. The wax template of the tooth is sprued using wax wire, then invested in a refractory investment material. The video shows the mould being heated to both expand it and prevent against thermal shock. A centrifugal casting process is shown, using an electrical furnace for melting the gold.
Tooth
This video shows the final stage of the production of a cast gold crown for a damaged tooth. The gold casting is cooled and removed from the mould. Sand blasting, an acid bath and then a series of abrasive burs are used to trim and finish the casting before a final polish is applied.
Food as Medicine: Preventing and Treating the Most Common Diseases with Diet
Food as Medicine
This is Dr. Greger's 2015 live presentation. Dr. Greger has scoured the world's scholarly literature on clinical nutrition and developed this new presentation based on the latest in cutting-edge research exploring the role diet may play in preventing, arresting, and even reversing some of our leading causes of death and disability. Subscribe to Dr. Greger’s free nutrition newsletter and get the Evidence-Based Eating Guide: A Healthy Living Resource from Dr. Greger and NutritionFacts.org.
Dr. Greger
Nutrition Facts.org published via YouTube.com
Middle Mediastinum and Heart - Anatomy and Dissection Guide
Anatomy
The anatomy shown in this video is based off of the UBC MEDD 411 gross anatomy checklist.
Dr. Majid Doroudi and Kamal Moghrabi
Tutorials
Breast Cancer Eliminated Using Keshe Technologies - Demo by Dr.Rodrigo Vildosola
Breast Cancer
Dr. Rodrigo Vildosola explains his method for treating breast cancer using Keshe Plasma Technologies. He gives an example of how he used this with one of his patients with stunning results. Warning: The video contains graphic images of a medical nature.
Dr. Rodrigo Vildosola
Medical Virology
Medical virology is always an interest to all healthcare disciplines, undergraduate and postgraduate students. These “Notes on Medical virology”, includes “what you really need to know”. The book comes in a new format, which places cases, keywords, facts and other considerations in colored tables and boxes only. As a result, extra spaces have been provided so that without expanding the length of the book the readers can enjoy a personal and practical learning experience.
Eman K. Aldigs
OMICS Group eBooks
Medicine
Health Case Studies is composed of eight separate health case studies. Each case study includes the patient narrative or story that models the best practice (at the time of publishing) in healthcare settings. Associated with each case is a set of specific learning objectives to support learning and facilitate educational strategies and evaluation. The case studies can be used online in a learning management system, in a classroom discussion, in a printed course pack or as part of a textbook created by the instructor. This flexibility is intentional and allows the educator to choose how best to convey the concepts presented in each case to the learner. Because these case studies were primarily developed for an electronic healthcare system, they are based predominantly in an acute healthcare setting. Educators can augment each case study to include primary healthcare settings, outpatient clinics, assisted living environments, and other contexts as relevant.
Glynda Rees
Rob Kruger
Janet Morrison
BCcampus
Cancers
1. A variety of different malignancies fall into the category of “Head and. Neck Cancers”. This chapter focuses on upper aerodigestive tract cancer. 2. Tobacco and alcohol use and human papillomavirus infection are common causes of head and neck cancers. 3. Most head and neck cancers are squamous cell carcinomas. 4. Treatment of head and neck cancers commonly requires some combination of surgery, radiation, and chemotherapy. Close cooperation between otolaryngologists, radiation oncologists, and medical oncologists is mandatory for successful treatment of these cancers. 5. Preservation of organ function in addition to cure of cancer, is an important goal of treatment. 6. Any patient with persistent symptoms of sore throat, hoarseness, difficulty swallowing or an enlarged cervical lymph node should be evaluated for possible head and neck cancer.
James Liebmann, MD, Ali Akalin MD, PhD., Liana Puscas, MD, MHS., Andrew Chen MD., Richard S. Pieters, MD
Health and Safety in Canadian Workplaces
Health and Safety
Workplace injuries happen every day and can profoundly affect workers, their families, and the communities they live in. This textbook provides workers with an introduction to effective injury prevention. The book pays particular attention to how issues of precarious employment, gender, and ill health can be better handled in Canadian occupational health and safety (OHS). This introduction to OHS differs from others because it contends that the practice of occupational health and safety can only be properly understood if we acknowledge that workers and employers have conflicting interests. Specifically, we investigate which workplace hazards are recognized and controlled, the manner in which these hazards are controlled, and who makes these decisions. These are all factors that reflect the broader political economy of employment and suggest that OHS is contested terrain.
Jason Foster
Bob Barnetson
Athabasca University Press
Metastatic Extramammary Paget's Disease: Pathogenesis and Novel Therapeutic Approach
Metastatic Extramammary Paget's Disease, Pathogenesis and Novel Therapeutic Approach
Extramammary Paget's disease (EMPD) is a rare, slow-growing, cutaneous adenocarcinoma that usually originates in the anogenital area and axillae outside the mammary glands. EMPD mostly progresses slowly and is often diagnosed as carcinoma in situ; however, upon becoming invasive, it promptly and frequently metastasizes to regional lymph nodes, leading to subsequent distant metastasis. To date, several chemotherapy regimens have been used to treat metastatic EMPD; however, they present limited effect and patients with distant metastasis exhibit a poor prognosis. Recently, basic and translational investigative research has elucidated factors and molecular mechanisms underlying the promotion of metastasis, which can lead to targeted therapy-based emerging treatment strategies. Here, we aim to discuss current therapies and their limitations; advancements in illustrating mechanisms promoting invasion, migration, and proliferation of EMPD tumor cells; and future therapeutic approaches for metastatic EMPD that may enhance clinical outcomes.
Keitaro Fukuda, Takeru Funakoshi
UMMS Authors
Publications
Cancer
This is the first lecture in the Bioinformatics for Cancer Genomics 2017 workshop hosted by the Canadian Bioinformatics Workshops. This lecture is by Trevor Pugh from the Princess Margaret Cancer Centre. For tutorials and lecture slides for this workshop, please visit bioinformaticsdotca.github.io.
Kevin MacLeod
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Medical
Cardiovascular
This sequence provides a comprehensive introduction to diseases of the cardiovascular system, how they present, how they are diagnosed, how they are prevented, and how they are treated. Students learn to identify the integral links between anatomy, physiology, pathology, and basic sciences with clinical medicine and other essential aspects of patient care for ambulatory and hospitalized patients who have cardiovascular disorders.
Kim A. Eagle, M.D.
University of Michigan
Power Point
Home Care
Home health services are those which are provided within the comforts of the home setting to help people avoid hospitalization or skilled nursing facility placement while they recover from illness, injury, or disability. Home health care may also be provided to people who suffer from chronic illnesses, those who have cognitive or physical disabilities or those who have been diagnosed with a terminal illness. Home Health Aide and Personal Care Aide are two of the fastest growing occupations. This text will provide you with the background necessary to begin working toward a career in the home care field.
Kimberly B. McLain
opensuny.org
Literature Reviews for Education and Nursing Graduate Students
Education
Nursing
Literature Reviews for Education and Nursing Graduate Students is an open textbook designed for students in graduate-level nursing and education programs. Its intent is to recognize the significant role the literature review plays in the research process and to prepare students for the work that goes into writing one. Developed for new graduate students and novice researchers just entering into the work of a chosen discipline, each of the eight chapters covers a component of the literature review process. Students will learn how to form a research question, search existing literature, synthesize results and write the review. The book contains examples, checklists, supplementary materials, and additional resources. Literature Reviews for Education and Nursing Graduate Students is written by two librarians with expertise guiding students through research and writing assignments, and is openly licensed.
Linda Frederiksen
Sue Phelps
Rebus Community
Physiology/ Pathophysiology of Coronary Blood Flow
Myocardial Ischemia Supply Demand Coronary Flow Reserve Determinants of Coronary Blood Flow Neural (autonomic) Mechanisms Endothelial Factors (Mechanisms) NOS, NO and ADMA
Louis G. D’Alecy
Slide
Genetic Disorders
This is the first lecture in the Bioinformatics of Genomic Medicine 2017 workshop hosted by the Canadian Bioinformatics Workshops. This lecture is by Michael Brudno from the Hospital for Sick Children. For tutorials and lecture slides for this workshop, please visit bioinformaticsdotca.github.io.
Michael Brudno
Bioinformatics Dot Ca published via YouTube.com
CANCER
This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents an overview of esophageal cancer, including etiology, epidemiology, screening, pathology, staging, and treatment.
Multiple Author
University of Massachusetts Medical School
Nutrition
As we get started on our journey into the world of health and nutrition, our first focus will be to demonstrate that nutritional science is an evolving field of study, continually being updated and supported by research, studies, and trials.
Tuberculosis
Open Accexx eBooks
Welcome to Human Anatomy and Physiology, an OpenStax College resource. We created this textbook with several goals in mind: accessibility, customization, and student engagement—helping students reach high levels of academic scholarship. Instructors and students alike will find that this textbook offers a thorough introduction to the content in an accessible format.
OpenStax
OpenStax College
Diseases of Children in the Subtropics and Tropics
Diseases of Children
Medicine & Health
Paediatrics is often thought of as following two main routes. One is that of ultra-technology and ever-narrower specialization. The other is recognition of child health in a community context, related to family circumstances (especially the health and welfare of mothers) and influenced by the environment, social stresses, economic limitations, cultural attitudes and practices, and policy decisions and priorities based on the political system. Neither is right, but rather a balance is needed. Thus, preventive programmes, such as immunization, depend on refined technology to produce appropriate vaccines and devise workable equipment for effective 'cold-chains'. Curative paediatrics, especially simplified methods in appropriate technology, has to be underpinned by science - both by necessity and to achieve acceptance by orthodox members of the Establishment. Examples include the work of gastroenterologists on the intestinal 'sodium pump' and how this can be 'primed' and made more effective by glucose. In this way, essential scientific credence has been given to the seemingly simple methods of oral rehydration, using prepared ORS packets or home-made mixtures of sugar and salt or dilute rice (or other staple) gruels. However, as always, it can be difficult to persuade physicians, including paediatricians, to acquire a community perspective, understanding and, still more, a truly active role. This is often in part because of their training which frequently remains predominantly clinical - 'we teach what we have been taught'. However, things are changing in some more enlightened training establishments, and the trend is certainly indicated in this Fourth Edition. Sound clinical work, as in a hospital environment, is vital and will always remain a major need. This approach alone cannot begin to touch the major issues of child health. Some of these may be beyond the scope of the paediatrician or of medical science. Nevertheless, an awareness of the need for an advocacy role has to be cultivated. In this way, advice and guidance may begin to move those in power towards policies which can improve community child health. The 'complete' paediatrician anywhere, but especially in less technically developed countries, often in tropical regions, needs to be much more than a blinkered 'vertical' /'horizontal' expert. Rather, there is a need for 'lateral' thinking, training and action. This implies realization of the wide range of factors needing consideration in child health work and also recognition of the value of a dove-tailed curative-preventive approach, as part of a team including paediatricians, nurses, community health workers and (importantly) parents, particularly mothers, in the community itself. The present edition of Diseases of Children in the Subtropics and Tropics moves in this direction and will most certainly be valuable not only as a clinical reference text. My hope is that it will also persuade its readers that a paediatrician should not only be clinically sound, but also able to recognize the wider community issues involved in the causation of problems and the need for imaginative interdisciplinary programes to improve the outlook for life and health of mothers and children in the Third World.
Paget Stanfield
Martin Brueton
Michael Chan
Michael Parkin
Tony Waterston
The Global Text Project
Introduction to Human Osteology
Osteology
Human Analogy
Physical anthropologists study human biological variation in the past and present. They are not only interested in the physical aspect of the body but also how biology, culture and environment interact to produce variation. Part of this variation is found in the bones and teeth. Since these are the hardest parts of the body, they have the greatest chance of being found in the archaeological record. Thus they form the bulk of direct information about the biological course of human evolution.
Roberta Hall
Kenneth Beals
Holm Neumann
Georg Neumann
Gwyn Madden
Malarial
Malaria was considered one of the most widespread disease-causing entities in the nineteenth century. It was associated with a variety of frailties far beyond fevers, ranging from idiocy to impotence. And yet, it was not a self-contained category. The reconsolidation of malaria as a diagnostic category during this period happened within a wider context in which cinchona plants and their most valuable extract, quinine, were reinforced as objects of natural knowledge and social control. In India, the exigencies and apparatuses of British imperial rule occasioned the close interactions between these histories. In the process, British imperial rule became entangled with a network of nonhumans that included, apart from cinchona plants and the drug quinine, a range of objects described as malarial, as well as mosquitoes. Malarial Subjects explores this history of the co-constitution of a cure and disease, of British colonial rule and nonhumans, and of science, medicine and empire. This title is also available as Open Access.
Rohan Deb Roy.
Cambridge University Press
Creative Clinical Teaching In The Health Professions
Clinical Teaching
Sherri Melrose
Caroline Park
Beth Perry
Independent
Urogynaecology
The field of Urogynaecology has expanded dramatically over the past decade with the advent of a number of new medical and surgical treatment modalities. The evidence base on pelvic floor dysfunction has also grown extensively. This multi-contributor text will prove invaluable to gynecology, urology and surgery registrars and specialists. Physiotherapists and nurses working in the field of Urogynaecology will also find it extremely useful.
Stephen Jeffery, Peter De Jong
University of Cape Town
Texxtbook
Nursing Care at the End of Life: What Every Clinician Should Know
Clinician
Nursing Care at the End of Life: What Every Clinician Should Know should be an essential component of basic educational preparation for the professional registered nurse student. Recent studies show that only one in four nurses feel confident in caring for dying patients and their families and less than 2% of overall content in nursing textbooks is related to end-of-life care, despite the tremendous growth in palliative and end-of-life care programs across the country. The purpose of this textbook is to provide an indepth look at death and dying in this country, including the vital role of the nurse in assisting patients and families along the journey towards the end of life. There is an emphasis throughout the book on the simple, yet understated value of effective interpersonal communication between the patient and clinician. The text provides a basic foundation of understanding death and dying, including a brief historical examination of some main conceptual models associated with how patients cope with impending loss. An overview of illness trajectories and models of care, such as hospice and palliative care are discussed. Lastly, the latest evidence-based approaches for pain and symptom management, ethical concerns, cultural considerations, care at the time of death, and grief/bereavement are examined. The goal of this text is to foster the necessary skills for nurses to provide compassionate care to individuals who are nearing the end of life and their families. Every chapter contains a “What You Should Know” section which highlights and reinforces foundational concepts.
Susan E. Lowey
Open SUNY Textbooks
Environmental
Science
Pharmacy
The earth's biogeochemical systems involve complex, dynamic processes that depend upon many factors. The three main factors upon which life on the earth depends.
University of California College Prep
Rice University, Houston, Texas
MCQs in Oral and Maxillofacial Surgery - Local and General Anesthetics
Surgery
Oral and Maxillofacial Surgery MCQs - Local and General Anesthetics Practice these MCQs for MDS entrance preparation in AIIMS, COMEDK, AIPG, PGI, BHU, etc. Also useful for ADA, NBDE, NDEB and other dental board exams. Please Share and Subscribe to Support us.
www.dentaldevotee.blogspot.com
Dentosphere : World of Dentistry published via YouTube.com
Creative Commons License .
Symptoms Of Type 2 Diabetes Creative Commons https://youtu.be/d8fBlTgn1_U This is always a surprising situation for most people around, who just go for regular check up to the doctor and end up knowing that they are suffering from one of the most common disease “diabetes “or “pre diabetes” condition. Even your doctor keep on warning you for the diabetes before or give you the idea that all such symptoms may lead to such terrible non ending disease. This thing is also so common that even if you are paying a lot of your attention on your body still it wouldn’t be an astonishing outcome that you are one of the victims of diabetes. Here are listed some highly observed warning signs for diabetes. 1. Need of Water Your body remains dehydrated and you always feel a need of water. Your mouth and lips dry out and you feel like drinking a huge amount of water all the time. Dehydration is linked with linked with your brain instead of your mouth. It is that even your mouth is dry and you don’t get any message from your brain you will never want the water. The brain cells always need a regular transfer of glucose beside the other part of your bodies. So; the system is followed as if your brain is overly concentrated with sugar water, it will order the supply of fluid from any other form to get diluted unease fluid surrounding each cell. In this way, your brain gets the water supply from other cells and leads towards the dehydration. This is the reason your body want to acquire more and more water. Most of the people have this misunderstanding that if you take soda you will remain hydrated. While soda is one of dangerous intake. So, if you feel the dehydrated most of the time, it means you need to get a checkup for diabetes. 2. Trips to the bathroom When you are taking a large amount of water supply in your body, then this is so sure that you need to urine. This also one of the alarming situations, which you need to take seriously because there is too much sugar in the blood vessel. All the water you take in will fill up your bladder and give you the feeling to pee. After which you feel thirsty and dehydrated again. This process of dehydration and hydration continue. Kidneys in this way release the excess amount of glucose from your body. And if the kidney can’t filter the waste properly, it means it is collecting toxins in your blood vessels. This condition can also damage the kidney on major level. 3. Weakness and Fatigue Sometimes you didn’t work out much and still your body is tired and exhausted, and you will never realize that this is cause of your diabetes which you are carrying inside. The actual problem lies here is that you can’t consume the glucose from your meals, the glucose is not readily enter into your cells. From all this less consumption of glucose and energy turn you weak and lazy. As you don’t gain energy from your meal, you still feel hungry after a while again. Here goes one more vital sign of diabetes. You should focus on each and every little aspect of your healthy and its related issues. 4. Lose Weight When you are suffering from diabetes, you start losing the weight in a specific pattern without any efforts of losing weight. If you are losing the weight, which even you are taking proper meals and food then it is one of the alarming condition. This kind of weight loss causes you to lose muscle mass. It happens in the part of the body which is looking for some energy and it breaks down the muscles of the cells. This is one of the clear symptoms of fatal diabetes. 5. Vision Disorder In the case, if the blood levels increase high ,it will drain all the fluid from all over body tissues .This also include you’re fluid fro Well come to our Channel: ''HEALTH & FITNESS'' Our channel ''HEALTH & FITNESS'' give us a lot of information about health and fitness. HEALTH & FITNESS is a most important for Healthy life. So keep watching to our channel for more videos HEALTH & FITNESS. Thanks For Subscribe ,Like and Share to our channel: https://goo.gl/UDorwZ Follow us on social media: Facebook https://goo.gl/vsGuJG Instagram https://goo.gl/F16iqI Youtube https://goo.gl/UDorwZ Google Plus https://goo.gl/pkrpC6 Disclaimer: The materials and the information contained on Natural Cures channel are provided for general and educational purposes only and do not constitute any legal, medical or other professional advice on any subject matter.None of the information on our videos is a substitute for a diagnosis and treatment by your health professional. Always seek the advice of your physician or other qualified health provider prior to starting any new diet or treatment and with any questions you may have regarding a medical condition. If you have or suspect that you have a medical problem, promptly contact your health care provider.
Health & Fitness published via YouTube.com
Standard YouTube License This video represents licensed content on YouTube, meaning that the content has been claimed by a YouTube content partner.
This video was created for the contest " anatomy by students, international contest" Category 5. ENT, ophthalmology, General Practice This video by Hershko Sarah is licensed under the Creative Commons Attribution ShareAlike 4.0 International license, or later version, see: https://creativecommons.org/licenses/by-sa/4.0/
Brain action published via YouTube.com
Introduction to The Anatomy of The Heart
Introduction to the anatomy of the heart, with explanation of the pericardium, myocardium, and endocardium.
Andrew Wolf published via YouTube.com
Creative Commons License This video represents licensed content on YouTube, meaning that the content has been claimed by a YouTube content partner.
Psych9B. Psychology Fundamentals. Lecture 1:
UCI Psych 9B: Psych Fundamentals (Fall 2015) Lec 01. Psych Fundamentals View the complete course: http://ocw.uci.edu/courses/psych_9bpsy_beh_11b_psychology_fundamentals.html Instructor: Mark Steyvers, Ph.D. License: Creative Commons CC-BY-SA Terms of Use: http://ocw.uci.edu/info. More courses at http://ocw.uci.edu Description: This one of the three courses that are a part of a three-quarter series, cross-listed as "Social Ecology Psy Beh P11 A, B, C" or "Social Sciences Psych 9 A, B, C." All three courses are offered every quarter and can be taken in any oder. The series is designed to give students a strong foundation in the major research areas of psychology, including such areas as human cognitive and social development, memory, language, emotional and social behavior, psychopathology, and neuroscience. This course sequence is required for students majoring in Psychology and Social Behavior in the School of Social Ecology and for students majoring in Psychology in the School of Social Sciences. These courses can also be taken by non-majors. In this course specifically, referred to as "Psy Beh P11B" or "Psych 9B," topics to be covered include memory, thinking, language, learning, and cognitive development Recorded on September 24, 2015. Required attribution: Steyvers, Mark. Psych Fundamentals 9B (UCI OpenCourseWare: University of California, Irvine), http://ocw.uci.edu/courses/psych_9bpsy_beh_11b_psychology_fundamentals.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License. (http://creativecommons.org/licenses/by-sa/3.0/deed.en_US).
UCI Open published via YouTube.com
Standard YouTube License
Psych9B. Psychology Fundamentals. Lecture 2:
UCI Psych 9B: Psych Fundamentals (Fall 2015) Lec 02. Psych Fundamentals View the complete course: http://ocw.uci.edu/courses/psych_9bpsy_beh_11b_psychology_fundamentals.html Instructor: Mark Steyvers, Ph.D. License: Creative Commons CC-BY-SA Terms of Use: http://ocw.uci.edu/info. More courses at http://ocw.uci.edu Description: This one of the three courses that are a part of a three-quarter series, cross-listed as "Social Ecology Psy Beh P11 A, B, C" or "Social Sciences Psych 9 A, B, C." All three courses are offered every quarter and can be taken in any oder. The series is designed to give students a strong foundation in the major research areas of psychology, including such areas as human cognitive and social development, memory, language, emotional and social behavior, psychopathology, and neuroscience. This course sequence is required for students majoring in Psychology and Social Behavior in the School of Social Ecology and for students majoring in Psychology in the School of Social Sciences. These courses can also be taken by non-majors. In this course specifically, referred to as "Psy Beh P11B" or "Psych 9B," topics to be covered include memory, thinking, language, learning, and cognitive development Recorded on September 29, 2015. Required attribution: Steyvers, Mark. Psych Fundamentals 9B (UCI OpenCourseWare: University of California, Irvine), http://ocw.uci.edu/courses/psych_9bpsy_beh_11b_psychology_fundamentals.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License. (http://creativecommons.org/licenses/by-sa/3.0/deed.en_US).
MIT 5.07SC Biological Chemistry, Fall 2013 View the complete course: http://ocw.mit.edu/5-07SCF13 Instructor: John Essigmann In this video, Professor Essigmann explores ketone bodies – what they are, how they are made, and how they are used in the body. He describes in detail the role ketone bodies play in diabetes and starvation scenarios. License: Creative Commons BY-NC-SA More information at http://ocw.mit.edu/terms More courses at http://ocw.mit.edu
MIT OpenCourseWare published via YouTube.com
Visit us (http://www.khanacademy.org/science/healthcare-and-medicine) for health and medicine content or (http://www.khanacademy.org/test-prep/mcat) for MCAT related content. These videos do not provide medical advice and are for informational purposes only. The videos are not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of a qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read or seen in any Khan Academy video. Created by Nauroz Syed. Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-pregnancy/v/preterm-labor?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn Missed the previous lesson? https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-pregnancy/v/uterine-inversion?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us/). About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s NCLEX-RN channel: https://www.youtube.com/channel/UCDx5cTeADCvKWgF9x_Qjz3g?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
khanacademymedicine published via YouTube.com
Heart Disease
Lifestyle approaches aren’t just safer and cheaper. They can work better, because you’re treating the actual cause of the disease. Input by Sofia Nelly Subscribe to Dr. Greger’s free nutrition newsletter at http://www.nutritionfacts.org/subscribe and get a free excerpt from his latest NYT Bestseller HOW NOT TO DIE. (All proceeds Dr. Greger receives from the sales of his books, DVDs, and speaking engagements go to support the 501c3 nonprofit that runs NutritionFacts.org.) You can imagine how overwhelming NutritionFacts.org might be for someone new to the site. With videos on more than 2,000 health topics, where do you even begin? Imagine someone stumbling onto the site when the new video-of-the-day is about how some spice can be effective in treating a particular form of arthritis. It would be easy to miss the forest for the trees. That’s why I created this new series of overview videos, which are basically taken straight from my hour-long live 2016 presentation How Not to Die: Preventing, Arresting, and Reversing Our Top 15 Killers (http://nutritionfacts.org/video/how-not-to-die). Stay tuned for: • How Not to Die from Cancer (http://nutritionfacts.org/video/how-not-to-die-from-cancer/) • How Not to Die from Diabetes (http://nutritionfacts.org/video/how-not-to-die-from-diabetes/) • How Not to Die from Kidney Disease (http://nutritionfacts.org/video/how-not-to-die-from-kidney-disease/) • How Not to Die from High Blood Pressure (http://nutritionfacts.org/video/how-not-to-die-from-high-blood-pressure) If this video inspired you to learn more about the role diet may play in preventing and treating heart disease, check out some of these other popular videos on the topic: • Heart Disease Starts in Childhood (http://nutritionfacts.org/video/heart-disease-starts-in-childhood) • Lifestyle Medicine: Treating the Causes of Disease (http://nutritionfacts.org/video/lifestyle-medicine-treating-the-causes-of-disease) • The Actual Benefit of Diet vs. Drugs (http://nutritionfacts.org/video/the-actual-benefit-of-diet-vs-drugs) • Optimal Cholesterol Level (http://nutritionfacts.org/video/optimal-cholesterol-level) • Physicians May Be Missing Their Most Important Tool (http://nutritionfacts.org/video/physicians-may-be-missing-their-most-important-tool) • Oxygenating Blood with Nitrate Rich Vegetables (http://nutritionfacts.org/video/oxygenating-blood-with-nitrate-rich-vegetables) • Is Fish Oil Just Snake Oil? (http://nutritionfacts.org/video/is-fish-oil-just-snake-oil) • Does Cholesterol Size Matter? (http://nutritionfacts.org/video/does-cholesterol-size-matter) • When Low Risk Means High Risk (http://nutritionfacts.org/video/when-low-risk-means-high-risk) • Low Carb Diets and Coronary Blood Flow (http://nutritionfacts.org/video/low-carb-diets-and-coronary-blood-flow) • Fully Consensual Heart Disease Treatment (http://nutritionfacts.org/video/fully-consensual-heart-disease-treatment) Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/how-not-to-die-from-heart-disease and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/how-not-to-die-from-heart-disease. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM http://www.NutritionFacts.org • Subscribe: http://www.NutritionFacts.org/subscribe • Donate: http://www.NutritionFacts.org/donate • HOW NOT TO DIE: http://nutritionfacts.org/book • Facebook: http://www.facebook.com/NutritionFacts.org • Twitter: http://www.twitter.com/nutrition_facts • Instagram: http://instagram.com/nutrition_facts_org/ • Google+: https://plus.google.com/+NutritionfactsOrgMD • Podcast: http://nutritionfacts.org/audio/
NutritionFacts.org published via YouTube.com
Hypotension
Hypotension is low blood pressure, especially in the arteries of the systemic circulation. Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. Hypotension is generally considered if systolic blood pressure less than 90 millimeters of mercury (mm Hg) or diastolic less than 60 mm Hg. However, in practice, blood pressure is considered too low only if noticeable symptoms are present. Hypotension is the opposite of hypertension, which is high blood pressure. It is best understood as a physiological state, rather than a disease. It is often associated with shock, though not necessarily indicative of it. For some people who exercise and are in top physical condition, low blood pressure is a sign of good health and fitness. For many people, excessively low blood pressure can cause dizziness and fainting or indicate serious heart, endocrine or neurological disorders. Severely low blood pressure can deprive the brain and other vital organs of oxygen and nutrients, leading to a life-threatening condition called shock. Input by Sofia Nelly
The Audiopedia published via YouTube.com
Toothache
In the past, before modern dentistry, people use to treat a tooth pain naturally because they had no other option. Nowadays, modern medicine has its own solutions, but there still several natural toothache remedies that people use just to avoid the visit to the dentist. There a few well-known causes of tooth pain, like Infected gums/ Gum Disease, Tooth Decay, Tooth eruption, An abnormal bite, Abscessed Tooth, Tooth Fracture or a damaged filling and all of them can cause pain, fever, headache, and swelling around the teeth. In this video, we represent 12 effective Home Toothache Remedies that will help you to get rid of the pain! Raw Garlic Garlic effectively fights fungi, bacteria, and viruses. You should crush the clove, leave it for a couple of minutes to activate its compounds, add some salt, and apply it on the painful tooth. You can also chew clove several times daily using the affected tooth. Ice To soothe the swelling and pain before going to the dentist, Apply an ice or a cold compress on the cheek. Salt Water Gargle Add a teaspoon of salt to a cup of boiling water, and as soon as it cools, gargle it for half a minute. This will alleviate pain and infections, remove debris, and ease the swelling. Chewing Gum The area around a broken tooth, or around a tooth which lacks the filling is irritated and painful. To relieve this pain, chew a gum on the opposite side of the mouth and apply it onto the painful tooth. Peppermint Tea A 2013 study found that peppermint oil has potent antiseptic properties which are useful against oral pathogens. You should drink peppermint tea with a teaspoon of peppermint leaves steeped for 15-20 minutes, to treat bad breath and toothaches. Clove Oil Clove oil is high in eugenol, which has powerful antiseptic and anesthetic properties that destroy germs and relieve gum pain. Studies have found that it is as effective as benzocaine in numbing pain. You should combine a few drops of this oil with a teaspoon of coconut oil, and use a cotton ball, apply the mixture on the painful area. When the place is numb, remove it, and wash the mouth. You can also chew a few cloves using the painful side of the mouth. Vanilla Extract The scent of vanilla soothes the anxiety linked to a toothache, and its alcohol content numbs the pain. Therefore, dab vanilla extracts on the finger and rub it onto the painful tooth twice daily to relieve the pain. Turmeric Paste Mix a teaspoon of turmeric powder, several drops of peppermint oil, and a tablespoon of coconut oil, and prepare a paste. Then, brush the teeth and leave it to act for a few minutes. And rinse. It has strong antiviral and antibacterial properties and will help you fight bad breath, irritations, gum redness, and tooth stains. Ginger Cayenne Paste Mix cayenne and ginger in equal amounts, add some water and prepare a paste. Then, apply it on the painful place using a cotton ball, and leave it to act in order to soothe the pain and swelling, fight off infection, and control bleeding. Myrrh According to RDH, “myrrh’s astringent properties help with inflammation, and a rinse can offer the added benefit of reducing bacteria”. To prepare a homemade myrrh rinse, simmer a teaspoon of myrrh in 2 cups of water, leave it to cool, and use it several times during the day. Essential Oils One 2014 study found that: “Essential oil rinses are found to be equally effective in inhibiting plaque. A study carried out by Pizzo et al. on plaque inhibitory effect of amine fluoride/stannous fluoride and essential oils showed no significant difference in efficacy of both. As chlorhexidine causes staining of teeth on long term use, essential oils can be used as an alternative to chlorhexidine rinse. Essential oils have shown to possess antimicrobial activity against subgingival pernio pathogens, too.” For best effects, use clove, tea tree oil, peppermint, myrrh, cinnamon, and spearmint. Acupressure Press the hand on the affected side, on the place where the base of the index finger and the thumb meet, and hold for several minutes. This will stimulate the release of endorphins, which will relieve the pain. Input by Sofia Nelly
Natural Remedies published via YouTube.com
A lecture on electrocardiograms by Dr. Kim Eagle, M.D. This lecture was taught as a part of the University of Michigan Medical School's M2 - Cardiovascular Sequence. View the course materials: http://open.umich.edu/education/med/m2/cardio/materials Creative Commons Attribution-Share Alike 3.0 License http://creativecommons.org/licenses/by-sa/3.0/ Help us caption and translate this video: http://www.amara.org/en/v/B4zX/
openmichigan published via YouTube.com
A lecture on chronic coronary artery disease by Dr. Kim Eagle, M.D. This lecture was taught as a part of the University of Michigan Medical School's M2 - Cardiovascular Sequence View the course materials: http://open.umich.edu/education/med/m2/cardio/materials Creative Commons Attribution-Share Alike 3.0 License http://creativecommons.org/licenses/by-sa/3.0/ Help us caption and translate this video: http://www.amara.org/en/videos/FXxnu5Eayfzl/info/chronic-coronary-artery-disease/
A lecture on acute coronary syndromes by Dr. Kim Eagle, M.D. This lecture was taught as a part of the University of Michigan Medical School's M2 - Cardiovascular Sequence View the course materials: http://open.umich.edu/education/med/m2/cardio/materials Creative Commons Attribution-Share Alike 3.0 License http://creativecommons.org/licenses/by-sa/3.0/ Help us caption and translate this video: http://www.amara.org/en/v/B4zZ/ Help us caption & translate this video! http://amara.org/v/B4zZ/
A lecture on evaluating a patient with chest pain by Dr. Kim Eagle, M.D. This lecture was taught as a part of the University of Michigan Medical School's M2 - Cardiovascular Sequence View the course materials: http://open.umich.edu/education/med/m2/cardio/materials Creative Commons Attribution-Share Alike 3.0 License http://creativecommons.org/licenses/by-sa/3.0/ Help us caption and translate this video: http://www.amara.org/en/v/B4zY/ Help us caption & translate this video! http://amara.org/v/B4zY/
Includes a display of instruments necessary for caries removal, a discussion of the steps and criteria involved and demonstration of a complete removal of a carious lesion. Orig. air date: JAN 8 74 This is part of the Open.Michigan collection at: http://open.umich.edu/education
UMichDent published via YouTube.com
Demonstrates on the skull and on a patient, various injection techniques. It also describes the basic dental chair position for injections. Orig. air date: NOV 8 74 This is part of the Open.Michigan collection at: http://open.umich.edu/education
Scaling and Root Planing: Part II Mandibular Teeth
Procedures for scaling and root planing the mandibular teeth. This is part of the Open.Michigan collection at: http://open.umich.edu/education
This is part of the Open.Michigan collection at: http://open.umich.edu/education
A lecture on Hemoglobinopathies by Dr. David Ginsburg, M.D. This lecture was taught as a part of the University of Michigan Medical School's M1 - Patients and Populations Sequence. View the course materials: http://open.umich.edu/education/med/m1/patientspop-genetics/fall2008/materials. Creative Commons Attribution-Non Commercial-Share Alike 3.0 License http://creativecommons.org/licenses/by-nc-sa/3.0/ Help us caption and translate this video: http://www.amara.org/en/v/B4zS/
A lecture on Hemoglobinopathies by Dr. David Ginsburg, M.D. This lecture was taught as a part of the University of Michigan Medical School's M1 - Patients and Populations Sequence. View the course materials: http://open.umich.edu/education/med/m1/patientspop-genetics/fall2008/materials. Creative Commons Attribution-Non Commercial-Share Alike 3.0 License http://creativecommons.org/licenses/by-nc-sa/3.0/ Help us caption and translate this video: http://www.amara.org/en/videos/LhfjxDzh1zha/info/hemoglobinopathies-part-2/
Surgical Excision of a Multi-Lobular, Recurrent, Bartholin Duct Cyst
Warning: Viewer discretion is advised, this medical content is graphic and may not be suitable for all viewers. This surgical video describes the etiology, diagnosis, and management of uncomplicated Bartholin duct cysts. The video provides specific attention to the pre-operative approach to recurrent and/or complicated Bartholin duct cysts, and demonstrates the surgical approach to a complicated, recurrent Bartholin duct cyst. Suggestions for surgical techniques are provided. Copyright 2011 Caren M Stalburg, Sarah Wallet, and Hope K. Haefner. Terms of Use: Creative Commons Attribution-Share Alike 3.0 License http://creativecommons.org/licenses/by-sa/3.0/ Help us caption and translate this video: http://www.amara.org/en/v/B5CA/ Help us caption & translate this video! http://amara.org/v/B5CA/
A lecture on Circulatory Derangements by Dr. Gerald Abrams, M.D. This lecture was taught as a part of the University of Michigan Medical School's M1 - Cardiovascular and Respiratory Sequence. View the course materials: http://open.umich.edu/education/med/m1/cardioresp/fall2008/materials Creative Commons Attribution-Non Commercial-Share Alike 3.0 License http://creativecommons.org/licenses/by-nc-sa/3.0/ Help us caption and translate this video on Amara.org: http://www.amara.org/en/v/B5Bs/ Help us caption & translate this video! http://amara.org/v/B5Bs/
A lecture on Circulatory Derangements by Dr. Gerald Abrams, M.D. This lecture was taught as a part of the University of Michigan Medical School's M1 - Cardiovascular and Respiratory Sequence. View the course materials: http://open.umich.edu/education/med/m1/cardioresp/fall2008/materials Creative Commons Attribution-Non Commercial-Share Alike 3.0 License http://creativecommons.org/licenses/by-nc-sa/3.0/ Help us caption and translate this video on Amara.org: http://www.amara.org/en/v/B5Bt/
Created by Vishal Punwani. Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-reproductive-system/v/basics-of-egg-development?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn Missed the previous lesson? https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-reproductive-system/v/spermatogenesis?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us/). About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s NCLEX-RN channel: https://www.youtube.com/channel/UCDx5cTeADCvKWgF9x_Qjz3g?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
Created by Vishal Punwani. Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-reproductive-system/v/meet-the-placenta?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn Missed the previous lesson? https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-reproductive-system/v/basics-of-egg-development?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us/). About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s NCLEX-RN channel: https://www.youtube.com/channel/UCDx5cTeADCvKWgF9x_Qjz3g?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
Created by Vishal Punwani. Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-reproductive-system-physiology/rn-reproductive-system/v/anatomy-of-the-male-reproductive-system?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn Missed the previous lesson?https://www.khanacademy.org/test-prep/nclex-rn/rn-integumentary-system-physiology/rn-integumentary-system/v/thermoregulation-by-muscles?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us/). About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s NCLEX-RN channel: https://www.youtube.com/channel/UCDx5cTeADCvKWgF9x_Qjz3g?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
www.EmpoweRN.com Hi Guys! Thank you so much for watching this channel :) Here is just a quick & simple nursing skill, that I really hope you enjoy! I appreciate all of your comments, likes & shares so much!! Really looking forward to growing with you!! Winners from Last weeks Giveaway!! Please email me at: Empower.RN@gmail.com :) 1. Stephanie Cianciolo 2. journeytoRN 3. Sabrina Botelho 4. John Navarro 5. LizRN Thank you: Life Medical Equipment for making this video possible! www.LifeMedicalEquipment.com Thank you: Johanna Pialisa Asis for editing this video! Disclaimer: These videos are intended for entertainment purposes only. Please follow the policy and procedures that your institution requires. Please note that the views, ideas & opinions expressed on this channel and in the videos on this channel are not necessarily of those of my employer or institution. The views expressed on this channel and in the videos channel do not represent medical advice. If you have specific medical concerns, please contact your physician. In order to protect patient privacy, all patient identifiers in all videos have been deleted or altered. The views expressed on this channel and in the videos on this channel are personal opinions. I am not an expert nor do I dispense medical advice or procedural specifications. The information I present is for general knowledge and entertainment purposes only. You need to refer to your own medical director, teachers and protocols for specific treatment information. It is your responsibility to know how best to treat your patient in your jurisdiction.
EmpoweRN published via YouTube.com
G Protein Coupled Receptors Nervous system physiology
Video ini menjelaskan tentang G-protein coupled receptor (reseptor G-protein bergandengan) yang juga biasa dikenal dengan GPCRs. G-protein coupled receptors hanya bisa ditemukan pada eukariot dan GPCRs adalah kelas yang terbesar dari semua reseptor membran.
OER-Unsyiah Lib published via YouTube.com
Pain Temperature BY : UPT Perpustakaan Universitas Syiah Kuala UKM Literasi Unsyiah
oerlib unsyiah1234 published via YouTube.com
What is Clinical Pharmacy Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/by-sa/3.0/ license. Clinical pharmacy is the branch of pharmacy in which pharmacists provide patient care that optimizes the use of medication and promotes health, wellness, and disease prevention. Clinical pharmacists care for patients in all health care settings but the clinical pharmacy movement initially began inside hospitals and clinics. Clinical pharmacists often work in collaboration with physicians, nurse practitioners, and other healthcare professionals. Clinical pharmacists have extensive education in the biomedical, pharmaceutical, socio-behavioural and clinical sciences. Most clinical pharmacists have a Doctor of Pharmacy (Pharm.D.) degree and many have completed one or more years of post-graduate training (for example, a general and/or specialty pharmacy residency). In the United States, clinical pharmacists can choose to become Board-certified through the Board of Pharmacy Specialties (BPS), which was organized in 1976 as an independent certification agency of the American Pharmacists Association. The BPS certifies pharmacists in the following specialities: ambulatory care pharmacy, critical care pharmacy, nuclear pharmacy, nutrition support pharmacy, oncology pharmacy, paediatric pharmacy, pharmacotherapy, and psychiatric pharmacy. Within the system of health care, clinical pharmacists are experts in the therapeutic use of medications. They routinely provide medication therapy evaluations and recommendations to patients and other health care professionals. Clinical pharmacists are a primary source of scientifically valid information and advice regarding the safe, appropriate, and cost-effective use of medications. Clinical pharmacists are also making themselves more readily available to the public. In the past, access to a clinical pharmacist was limited to hospitals, clinics, or educational institutions. However, clinical pharmacists are making themselves available through a medication information hotline, and reviewing medication lists, all in an effort to prevent medication errors in the foreseeable future. In the United Kingdom, clinical pharmacists are routinely involved in the direct care of patients within hospitals, and increasingly, in doctors surgeries. They also develop post registration professional education, professional curricula for workforce development, provide expertise on the use of medicines to national organizations such as NICE, the Department of Health, and the MHRA, and develop medicines guidelines for use in therapeutic areas. Clinical pharmacists interact directly with patients in several different ways. They use their knowledge of medication (including dosage, drug interactions, side effects, expense, effectiveness, etc.) to determine if a medication plan is appropriate for their patient. If it is not, the pharmacist will consult the primary physician to ensure that the patient is on the proper medication plan. The pharmacist also works to educate their patients on the importance of taking and finishing their medications. Studies conducted into Pharmacist-led Chronic Disease Management show that it was associated with effects similar to usual care and might improve physiological goal attainment. In some states, clinical pharmacists are given prescriptive authority under protocol with a medical provider, and their scope of practice is constantly evolving. In the United Kingdom clinical pharmacists are given independent prescriptive authority. Basic components of clinical pharmacy practice include: Prescribing drugs, administering drugs, monitoring prescriptions, managing drug use, and counselling patients.
Care in Healthcare: Reflections on Theory and Practice
Healthcare
This book examines the concept of care and care practices in healthcare from the interdisciplinary perspectives of continental philosophy, care ethics, the social sciences, and anthropology. Areas addressed include dementia care, midwifery, diabetes care, psychiatry, and reproductive medicine. Special attention is paid to ambivalences and tensions within both the concept of care and care practices. Contributions in the first section of the book explore phenomenological and hermeneutic approaches to care and reveal historical precursors to care ethics. Empirical case studies and reflections on care in institutionalised and standardised settings form the second section of the book. The concluding chapter, jointly written by many of the contributors, points at recurring challenges of understanding and practicing care that open up the field for further research and discussion. This collection will be of great value to scholars and practitioners of medicine, ethics, philosophy, social science and history.
Palgrave Macmillan
Dementia
Open Access Books
Field Trials of Health Interventions: A Toolbox
Health Interventions
Abstract Before new interventions are released into disease control programmes, it is essential that they are carefully evaluated in `field trials'. These may be complex and expensive undertakings, requiring the follow-up of hundreds, or thousands, of individuals, often for long periods. Descriptions of the detailed procedures and methods used in the trials that have been conducted have rarely been published. A consequence of this, individuals planning such trials have few guidelines available and little access to knowledge accumulated previously, other than their own. In this open-access online guide, practical issues in trial design and conduct are discussed fully and in sufficient detail. It has been compiled by an international group of over 30 authors with direct experience in the design, conduct, and analysis of field trials in low and middle income countries and is based on their accumulated knowledge and experience
Oxford University Press
Interface Oral Health Science 2016: Innovative Research on Biosis–Abiosis Intelligent Interface
This volume broadens understanding of dentistry and promotes interdisciplinary research across a wide range of related fields, based on the symposium entitled "Innovative Research for Biosis–Abiosis Intelligent Interface 2016". It aims to create highly functional and autonomic intelligent interface by combining highly functional interface science with the technology of an evaluation and a control at the interface, with the various topics of biomaterials, innovation for oral science and application, regenerative oral science, and medical engineering. Since 2002, the Tohoku University Graduate School of Dentistry has hosted “Interface Oral Health Science” several times as the main theme of dental research in the twenty-first century, and this is the sixth proceedings of the symposiums following the ones in 2005, 2007, 2009, 2011, and 2014. This book benefits not only dental scientists but also other health scientists including medical physicians and pharmacologists, material scientists, engineers, and any scientist who is involved in variety of disciplines.
Springer Nature
Public Health Ethics: Cases Spanning the Globe
Public Health
This Open Access book highlights the ethical issues and dilemmas that arise in the practice of public health. It is also a tool to support instruction, debate, and dialogue regarding public health ethics. Although the practice of public health has always included consideration of ethical issues, the field of public health ethics as a discipline is a relatively new and emerging area. There are few practical training resources for public health practitioners, especially resources which include discussion of realistic cases which are likely to arise in the practice of public health. This work discusses these issues on a case to case basis and helps create awareness and understanding of the ethics of public health care. The main audience for the casebook is public health practitioners, including front-line workers, field epidemiology trainers and trainees, managers, planners, and decision makers who have an interest in learning about how to integrate ethical analysis into their day to day public health practice. The casebook is also useful to schools of public health and public health students as well as to academic ethicists who can use the book to teach public health ethics and distinguish it from clinical and research ethics.
The manual contains the following labs: Blood Composition Blood Typing Heart Anatomy Cardiovascular Physiology Systemic Blood Vessels Anatomy of the Respiratory System Physiology of the Respiratory System Renal Anatomy Urinalysis Digestive System Anatomy Digestive Physiology Male Reproductive System Female Reproductive System
Respiratory
The job of the respiratory system is to take oxygen from the air we breathe and get it to different parts of the body. Our bodies and the cells in them need oxygen (written with the chemical symbol O2) to live. Our cells give off carbon dioxide (written with the chemical symbol CO2) as a waste product or something they don’t need any more. The respiratory system takes this carbon dioxide out of the body. The main organ of the respiratory system is the lungs. The respiratory system starts when you take a breath. There is a muscle called the diaphragm that is at the bottom of the rib cage. It helps draw air into the lungs. Once a breath is taken, the air travels through the mouth or nose and travels through the windpipe into the lungs. Once the air is down the windpipe, it splits one of two directions into tubes called bronchi and then into the lungs. The bronchi branch off into more and more smaller tubes. At the very end of these are small sacs called alveoli. In the alveoli, the respiratory system works with the circulatory system. Small blood vessels take oxygen from the alveoli to the heart for distribution to the rest of the body. Blood also brings carbon dioxide to be exhaled back out. When we breathe in or inhale, the air coming into the body has a lot of oxygen. When we breathe out or exhale, the air has more carbon dioxide.
Image
Circulatory
The circulatory system includes the heart, blood, and a huge network of blood vessels that carry blood all over the body. The job of the circulatory system is to deliver oxygen to cells all over the body and then to carry out waste product like carbon dioxide. The heart is an organ made out of muscle. It’s job is to pump blood through the body. The heart has four main sections or chambers: Right atrium Right ventricle Left atrium Left ventricle Blood flows into the right atrium through two large blood vessels called the superior vena cava (from the upper body) and the inferior vena cava (from the lower body). From there blood moves to the right ventricle. It then travels to the lungs to get oxygen. Blood coming back from the lungs enters the left atrium and then into the left ventricle. From there it leaves the heart through the aortic valve and goes into the aorta. This is the largest artery in the body, and it leads to all parts of the body. There are many kinds blood vessels that carry blood around the body. Arteries carry blood away from the heart. (You can remember arteries and away.) Veins carry blood back to the heart. Blood that is coming from the lungs has lots of fresh oxygen in it and is bright red. After the oxygen is delivered to cells and carbon dioxide is picked up, the blood is darker colored. Blood is made up of a liquid called plasma and three kinds of cells. Red blood cells carry oxygen to the various parts of the body. White blood cells help fight disease. Platelets help blood clot.
Digestive
Our bodies need food to live and grow. The digestive system takes food and carries it to all the parts of the body. The beginning of the digestive system is the mouth and teeth. Food that we eat has to be broken down into nutrients that cells in our bodies can use. This starts with the teeth and tongue grinding food into smaller pieces. Saliva also helps break down food. Then the food is swallowed and goes down the esophagus, a tube that goes from the mouth to the stomach. The stomach breaks down the food further. Gastric juices that have acids and enzymes in them that help the process. Then the food goes to the small intestine. This is a long twisting tube that fills up much of your lower abdomen area. It is where most of the digestion occurs. The liver produces bile, and the pancreas produces juices that help break food down. Small blood vessels line the walls of the small intestine. Once the food is broken down, the nutrients are absorbed by these blood vessels. The blood then carries the nutrients to cells all over the body. The part of the food that is left moves on to the large intestine.
Excretory
After food goes through the digestive system, the parts that are not digested need to be gotten rid of. That is the job of the excretory system. Unabsorbed food goes to the large intestine. The liver also filters out solid particles of waste from the blood. These solid wastes are removed from the body through the rectum, which is at the end of the large intestine. Liquid wastes are filtered by the kidneys, a part of the excretory system. The kidneys have long tubes coming out of them called ureters that drain liquid into the bladder. The bladder stores liquid waste called urine until it is passed out of the body through the urethra.
Human Leg
Human Skeleton
The human skeleton provides shape and form to the human body Our vital organs in our body are protected by our skeleton. More specifically our brain which is protected by what is called the skull and our heart and lungs are protected by our rib cage. Bones are connected by our ligaments and where the bones meet eachother is called a joint. Muscles are connected to the bones by tendons Bones are sonnected to each other by ligaments Blood cells are produced by the marrow located in some bones How your bones move! Muscles pull on the bones, making them move and when muscles contract the bones attached act as levers which makes the body move.
Cardio
Cardio Exercises Below 1) Jog. You can do this outside on a treadmill or however you like. 2) Jump Rope routine 1 3) 10 Minute Jump Rope routine 4) Exercise Bikes 5) Sports Playing
Chambers and Circulation through the Heart
Chambers
Circulation
Heart
Dual System of the Human Blood Circulation. Blood flows from the right atrium to the right ventricle, where it is pumped into the pulmonary circuit. The blood in the pulmonary artery branches is low in oxygen but relatively high in carbon dioxide. Gas exchange occurs in the pulmonary capillaries (oxygen into the blood, carbon dioxide out), and blood high in oxygen and low in carbon dioxide is returned to the left atrium. From here, blood enters the left ventricle, which pumps it into the systemic circuit. Following exchange in the systemic capillaries (oxygen and nutrients out of the capillaries and carbon dioxide and wastes in), blood returns to the right atrium and the cycle is repeated.
Arm
Bones
Shoulder Joint
The shoulder joint is called the glenohumeral joint. This is a ball-and-socket joint formed by the articulation between the head of the humerus and the glenoid cavity of the scapula ([link]). This joint has the largest range of motion of any joint in the body. However, this freedom of movement is due to the lack of structural support and thus the enhanced mobility is offset by a loss of stability. The large range of motions at the shoulder joint is provided by the articulation of the large, rounded humeral head with the small and shallow glenoid cavity, which is only about one third of the size of the humeral head. The socket formed by the glenoid cavity is deepened slightly by a small lip of fibrocartilage called the glenoid labrum, which extends around the outer margin of the cavity. The articular capsule that surrounds the glenohumeral joint is relatively thin and loose to allow for large motions of the upper limb. Some structural support for the joint is provided by thickenings of the articular capsule wall that form weak intrinsic ligaments. These include the coracohumeral ligament, running from the coracoid process of the scapula to the anterior humerus, and three ligaments, each called a glenohumeral ligament, located on the anterior side of the articular capsule. These ligaments help to strengthen the superior and anterior capsule walls. However, the primary support for the shoulder joint is provided by muscles crossing the joint, particularly the four rotator cuff muscles. These muscles (supraspinatus, infraspinatus, teres minor, and subscapularis) arise from the scapula and attach to the greater or lesser tubercles of the humerus. As these muscles cross the shoulder joint, their tendons encircle the head of the humerus and become fused to the anterior, superior, and posterior walls of the articular capsule. The thickening of the capsule formed by the fusion of these four muscle tendons is called the rotator cuff. Two bursae, the subacromial bursa and the subscapular bursa, help to prevent friction between the rotator cuff muscle tendons and the scapula as these tendons cross the glenohumeral joint. In addition to their individual actions of moving the upper limb, the rotator cuff muscles also serve to hold the head of the humerus in position within the glenoid cavity. By constantly adjusting their strength of contraction to resist forces acting on the shoulder, these muscles serve as “dynamic ligaments” and thus provide the primary structural support for the glenohumeral joint.
Levels of Structural Organization of the Human Body
Human Body
Before you begin to study the different structures and functions of the human body, it is helpful to consider its basic architecture; that is, how its smallest parts are assembled into larger structures. It is convenient to consider the structures of the body in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, organisms and biosphere. To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of which are hydrogen, oxygen, carbon, nitrogen, calcium, and iron. The smallest unit of any of these pure substances (elements) is an atom. Atoms are made up of subatomic particles such as the proton, electron and neutron. Two or more atoms combine to form a molecule, such as the water molecules, proteins, and sugars found in living things. Molecules are the chemical building blocks of all body structures. A cell is the smallest independently functioning unit of a living organism. Even bacteria, which are extremely small, independently-living organisms, have a cellular structure. Each bacterium is a single cell. All living structures of human anatomy contain cells, and almost all functions of human physiology are performed in cells or are initiated by cells. A human cell typically consists of flexible membranes that enclose cytoplasm, a water-based cellular fluid together with a variety of tiny functioning units called organelles. In humans, as in all organisms, cells perform all functions of life. A tissue is a group of many similar cells (though sometimes composed of a few related types) that work together to perform a specific function. An organ is an anatomically distinct structure of the body composed of two or more tissue types. Each organ performs one or more specific physiological functions. An organ system is a group of organs that work together to perform major functions or meet physiological needs of the body.
Organ Systems
Normal childbirth is driven by a positive feedback loop. A positive feedback loop results in a change in the body’s status, rather than a return to homeostasis.
Dorsal
Ventral Body
The posterior (dorsal) and anterior (ventral) cavities are each subdivided into smaller cavities. In the posterior (dorsal) cavity, the cranial cavity houses the brain, and the spinal cavity (or vertebral cavity) encloses the spinal cord. Just as the brain and spinal cord make up a continuous, uninterrupted structure, the cranial and spinal cavities that house them are also continuous. The brain and spinal cord are protected by the bones of the skull and vertebral column and by cerebrospinal fluid, a colorless fluid produced by the brain, which cushions the brain and spinal cord within the posterior (dorsal) cavity. The anterior (ventral) cavity has two main subdivisions: the thoracic cavity and the abdominopelvic cavity (see [link]). The thoracic cavity is the more superior subdivision of the anterior cavity, and it is enclosed by the rib cage. The thoracic cavity contains the lungs and the heart, which is located in the mediastinum. The diaphragm forms the floor of the thoracic cavity and separates it from the more inferior abdominopelvic cavity. The abdominopelvic cavity is the largest cavity in the body. Although no membrane physically divides the abdominopelvic cavity, it can be useful to distinguish between the abdominal cavity, the division that houses the digestive organs, and the pelvic cavity, the division that houses the organs of reproduction.
Regions and Quadrants of the Peritoneal Cavity
Regions
Quadrants
The more detailed regional approach subdivides the cavity with one horizontal line immediately inferior to the ribs and one immediately superior to the pelvis, and two vertical lines drawn as if dropped from the midpoint of each clavicle (collarbone). There are nine resulting regions. The simpler quadrants approach, which is more commonly used in medicine, subdivides the cavity with one horizontal and one vertical line that intersect at the patient’s umbilicus (navel)
Membrane
A serous membrane (also referred to a serosa) is one of the thin membranes that cover the walls and organs in the thoracic and abdominopelvic cavities. The parietal layers of the membranes line the walls of the body cavity (pariet- refers to a cavity wall). The visceral layer of the membrane covers the organs (the viscera). Between the parietal and visceral layers is a very thin, fluid-filled serous space, or cavity There are three serous cavities and their associated membranes. The pleura is the serous membrane that surrounds the lungs in the pleural cavity; the pericardium is the serous membrane that surrounds the heart in the pericardial cavity; and the peritoneum is the serous membrane that surrounds several organs in the abdominopelvic cavity.The serous membranes form fluid-filled sacs, or cavities, that are meant to cushion and reduce friction on internal organs when they move, such as when the lungs inflate or the heart beats. Both the parietal and visceral serosa secrete the thin, slippery serous fluid located within the serous cavities. The pleural cavity reduces friction between the lungs and the body wall. Likewise, the pericardial cavity reduces friction between the heart and the wall of the pericardium. The peritoneal cavity reduces friction between the abdominal and pelvic organs and the body wall. Therefore, serous membranes provide additional protection to the viscera they enclose by reducing friction that could lead to inflammation of the organs.
X-Ray
High energy electromagnetic radiation allows the internal structures of the body, such as bones, to be seen in X-rays like these
(a) The results of a CT scan of the head are shown as successive transverse sections. (b) An MRI machine generates a magnetic field around a patient. (c) PET scans use radiopharmaceuticals to create images of active blood flow and physiologic activity of the organ or organs being targeted. (d) Ultrasound technology is used to monitor pregnancies because it is the least invasive of imaging techniques and uses no electromagnetic radiation.
Elements
The main elements that compose the human body are shown from most abundant to least abundant.
Adenosine Triphosphate
The nucleotide adenosine triphosphate (ATP), is composed of a ribose sugar, an adenine base, and three phosphate groups ([link]). ATP is classified as a high energy compound because the two covalent bonds linking its three phosphates store a significant amount of potential energy. In the body, the energy released from these high energy bonds helps fuel the body’s activities, from muscle contraction to the transport of substances in and out of cells to anabolic chemical reactions. When a phosphate group is cleaved from ATP, the products are adenosine diphosphate (ADP) and inorganic phosphate (Pi). This hydrolysis reaction can be written: ATP + H2O → ADP + Pi + energy Removal of a second phosphate leaves adenosine monophosphate (AMP) and two phosphate groups. Again, these reactions also liberate the energy that had been stored in the phosphate-phosphate bonds. They are reversible, too, as when ADP undergoes phosphorylation. Phosphorylation is the addition of a phosphate group to an organic compound, in this case, resulting in ATP. In such cases, the same level of energy that had been released during hydrolysis must be reinvested to power dehydration synthesis. Cells can also transfer a phosphate group from ATP to another organic compound. For example, when glucose first enters a cell, a phosphate group is transferred from ATP, forming glucose phosphate (C6H12O6—P) and ADP. Once glucose is phosphorylated in this way, it can be stored as glycogen or metabolized for immediate energy.
Fluorescence-stained Cell Undergoing Mitosis
Mitosis
Cell
A lung cell from a newt, commonly studied for its similarity to human lung cells, is stained with fluorescent dyes. The green stain reveals mitotic spindles, red is the cell membrane and part of the cytoplasm, and the structures that appear light blue are chromosomes. This cell is in anaphase of mitosis.
Cell Membrane
The cell membrane of the cell is a phospholipid bilayer containing many different molecular components, including proteins and cholesterol, some with carbohydrate groups attached.
Simple Diffusion across the Cell (Plasma) Membrane
Cell (Plasma) Membrane
The structure of the lipid bilayer allows small, uncharged substances such as oxygen and carbon dioxide, and hydrophobic molecules such as lipids, to pass through the cell membrane, down their concentration gradient, by simple diffusion.
Facilitated Diffusion
(a) Facilitated diffusion of substances crossing the cell (plasma) membrane takes place with the help of proteins such as channel proteins and carrier proteins. Channel proteins are less selective than carrier proteins, and usually mildly discriminate between their cargo based on size and charge. (b) Carrier proteins are more selective, often only allowing one particular type of molecule to cross.
Sodium-Potassium Pump
The sodium-potassium pump is found in many cell (plasma) membranes. Powered by ATP, the pump moves sodium and potassium ions in opposite directions, each against its concentration gradient. In a single cycle of the pump, three sodium ions are extruded from and two potassium ions are imported into the cell.
Endocytosis
Endocytosis is a form of active transport in which a cell envelopes extracellular materials using its cell membrane. (a) In phagocytosis, which is relatively nonselective, the cell takes in a large particle. (b) In pinocytosis, the cell takes in small particles in fluid. (c) In contrast, receptor-mediated endocytosis is quite selective. When external receptors bind a specific ligand, the cell responds by endocytosing the ligand.
Exocytosis
Exocytosis is much like endocytosis in reverse. Material destined for export is packaged into a vesicle inside the cell. The membrane of the vesicle fuses with the cell membrane, and the contents are released into the extracellular space.
Fatty
Acid
The level of saturation of a fatty acid affects its shape. (a) Saturated fatty acid chains are straight. (b) Unsaturated fatty acid chains are kinked.
Human Cell
While this image is not indicative of any one particular human cell, it is a prototypical example of a cell containing the primary organelles and internal structures.
Endoplasmic Reticulum
(a) The ER is a winding network of thin membranous sacs found in close association with the cell nucleus. The smooth and rough endoplasmic reticula are very different in appearance and function (source: mouse tissue). (b) Rough ER is studded with numerous ribosomes, which are sites of protein synthesis (source: mouse tissue). EM × 110,000. (c) Smooth ER synthesizes phospholipids, steroid hormones, regulates the concentration of cellular Ca++, metabolizes some carbohydrates, and breaks down certain toxins (source: mouse tissue)
Golgi Apparatus
(a) The Golgi apparatus manipulates products from the rough ER, and also produces new organelles called lysosomes. Proteins and other products of the ER are sent to the Golgi apparatus, which organizes, modifies, packages, and tags them. Some of these products are transported to other areas of the cell and some are exported from the cell through exocytosis. Enzymatic proteins are packaged as new lysosomes (or packaged and sent for fusion with existing lysosomes). (b) An electron micrograph of the Golgi apparatus.
Mitochondrion
The mitochondria are the energy-conversion factories of the cell. (a) A mitochondrion is composed of two separate lipid bilayer membranes. Along the inner membrane are various molecules that work together to produce ATP, the cell’s major energy currency. (b) An electron micrograph of mitochondri
The Three Components of the Cytoskeleton
Cytoskeleton
The cytoskeleton consists of (a) microtubules, (b) microfilaments, and (c) intermediate filaments. The cytoskeleton plays an important role in maintaining cell shape and structure, promoting cellular movement, and aiding cell division.
Nucleus
The nucleus is the control center of the cell. The nucleus of living cells contains the genetic material that determines the entire structure and function of that cell.
Muscle Cell
Unlike cardiac muscle cells and smooth muscle cells, which have a single nucleus, a skeletal muscle cell contains many nuclei, and is referred to as “multinucleated.” These muscle cells are long and fibrous (often referred to as muscle fibers). During development, many smaller cells fuse to form a mature muscle fiber. The nuclei of the fused cells are conserved in the mature cell, thus imparting a multinucleate characteristic to mature muscle cells.
DNA
Strands of DNA are wrapped around supporting histones. These proteins are increasingly bundled and condensed into chromatin, which is packed tightly into chromosomes when the cell is ready to divide.
The DNA double helix is composed of two complementary strands. The strands are bonded together via their nitrogenous base pairs using hydrogen bonds.
DNA Replication
DNA replication faithfully duplicates the entire genome of the cell. During DNA replication, a number of different enzymes work together to pull apart the two strands so each strand can be used as a template to synthesize new complementary strands. The two new daughter DNA molecules each contain one pre-existing strand and one newly synthesized strand. Thus, DNA replication is said to be “semiconservative
Genetic Code
DNA holds all of the genetic information necessary to build a cell’s proteins. The nucleotide sequence of a gene is ultimately translated into an amino acid sequence of the gene’s corresponding protein.
mRNA
In the first of the two stages of making protein from DNA, a gene on the DNA molecule is transcribed into a complementary mRNA molecule.
In the nucleus, a structure called a spliceosome cuts out introns (noncoding regions) within a pre-mRNA transcript and reconnects the exons.
RNA
Protein
During translation, the mRNA transcript is “read” by a functional complex consisting of the ribosome and tRNA molecules. tRNAs bring the appropriate amino acids in sequence to the growing polypeptide chain by matching their anti-codons with codons on the mRNA strand.
From DNA to Protein: Transcription through Translation
Transcription within the cell nucleus produces an mRNA molecule, which is modified and then sent into the cytoplasm for translation. The transcript is decoded into a protein with the help of a ribosome and tRNA molecules.
A Homologous Pair of Chromosomes with their Attached Sister Chromatids
Chromosomes
The red and blue colors correspond to a homologous pair of chromosomes. Each member of the pair was separately inherited from one parent. Each chromosome in the homologous pair is also bound to an identical sister chromatid, which is produced by DNA replication, and results in the familiar “X” shape.
The stages of cell division oversee the separation of identical genetic material into two new nuclei, followed by the division of the cytoplasm.
Hematopoiesis
The process of hematopoiesis involves the differentiation of multipotent cells into blood and immune cells. The multipotent hematopoietic stem cells give rise to many different cell types, including the cells of the immune system and red blood cells.
Stem Cells
The capacity of stem cells to differentiate into specialized cells make them potentially valuable in therapeutic applications designed to replace damaged cells of different body tissues.
Cervical Tissue
This figure is a view of the regular architecture of normal tissue contrasted with the irregular arrangement of cancerous cells.
Tissue
Body
The four types of tissues are exemplified in nervous tissue, stratified squamous epithelial tissue, cardiac muscle tissue, and connective tissue in small intestine. Clockwise from nervous tissue
Tissues
Embryonic
The zygote, or fertilized egg, is a single cell formed by the fusion of an egg and sperm. After fertilization the zygote gives rise to rapid mitotic cycles, generating many cells to form the embryo. The first embryonic cells generated have the ability to differentiate into any type of cell in the body and, as such, are called totipotent, meaning each has the capacity to divide, differentiate, and develop into a new organism. As cell proliferation progresses, three major cell lineages are established within the embryo. As explained in a later chapter, each of these lineages of embryonic cells forms the distinct germ layers from which all the tissues and organs of the human body eventually form. Each germ layer is identified by its relative position: ectoderm (ecto- = “outer”), mesoderm (meso- = “middle”), and endoderm (endo- = “inner”). The types of tissues and organs associated with the each of the three germ layers. Note that epithelial tissue originates in all three layers, whereas nervous tissue derives primarily from the ectoderm and muscle tissue from mesoderm.
The two broad categories of tissue membranes in the body are (1) connective tissue membranes, which include synovial membranes, and (2) epithelial membranes, which include mucous membranes, serous membranes, and the cutaneous membrane, in other words, the skin.
The three basic types of cell-to-cell junctions are tight junctions, gap junctions, and anchoring junctions.
Epithelial Tissue
Simple epithelial tissue is organized as a single layer of cells and stratified epithelial tissue is formed by several layers of cells.
(a) In the lining of the small intestine, columnar epithelium cells are interspersed with goblet cells. (b) The arrows in this micrograph point to the mucous-secreting goblet cells.
Epithelial Tissue Cells
A stratified epithelium consists of several stacked layers of cells. This epithelium protects against physical and chemical wear and tear. The stratified epithelium is named by the shape of the most apical layer of cells, closest to the free space. Stratified squamous epithelium is the most common type of stratified epithelium in the human body. The apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The top layer may be covered with dead cells filled with keratin. Mammalian skin is an example of this dry, keratinized, stratified squamous epithelium. The lining of the mouth cavity is an example of an unkeratinized, stratified squamous epithelium. Stratified cuboidal epithelium and stratified columnar epithelium can also be found in certain glands and ducts, but are uncommon in the human body. Another kind of stratified epithelium is transitional epithelium, so-called because of the gradual changes in the shapes of the apical cells as the bladder fills with urine. It is found only in the urinary system, specifically the ureters and urinary bladder. When the bladder is empty, this epithelium is convoluted and has cuboidal apical cells with convex, umbrella shaped, apical surfaces. As the bladder fills with urine, this epithelium loses its convolutions and the apical cells transition from cuboidal to squamous. It appears thicker and more multi-layered when the bladder is empty, and more stretched out and less stratified when the bladder is full and distended. summarizes the different categories of epithelial cell tissue cells.
Glands
Exocrine glands are classified by their structure.
Glandular Secretion
(a) In merocrine secretion, the cell remains intact. (b) In apocrine secretion, the apical portion of the cell is released, as well. (c) In holocrine secretion, the cell is destroyed as it releases its product and the cell itself becomes part of the secretion.
These glands secrete oils that lubricate and protect the skin. They are holocrine glands and they are destroyed after releasing their contents. New glandular cells form to replace the cells that are lost
Fibroblasts produce this fibrous tissue. Connective tissue proper includes the fixed cells fibrocytes, adipocytes, and mesenchymal cells.
Adipose Tissue
This is a loose connective tissue that consists of fat cells with little extracellular matrix. It stores fat for energy and provides insulation.
Reticular Tissue
This is a loose connective tissue made up of a network of reticular fibers that provides a supportive framework for soft organs.
Dense Connective Tissue
(a) Dense regular connective tissue consists of collagenous fibers packed into parallel bundles. (b) Dense irregular connective tissue consists of collagenous fibers interwoven into a mesh-like network. From top,
Types of Cartilage
Cartilage is a connective tissue consisting of collagenous fibers embedded in a firm matrix of chondroitin sulfates. (a) Hyaline cartilage provides support with some flexibility. The example is from dog tissue. (b) Fibrocartilage provides some compressibility and can absorb pressure. (c) Elastic cartilage provides firm but elastic support. From top,
Neuron
The cell body of a neuron, also called the soma, contains the nucleus and mitochondria. The dendrites transfer the nerve impulse to the soma. The axon carries the action potential away to another excitable cell.
Nervous tissue is made up of neurons and neuroglia. The cells of nervous tissue are specialized to transmit and receive impulses
Skin
The skin is composed of two main layers: the epidermis, made of closely packed epithelial cells, and the dermis, made of dense, irregular connective tissue that houses blood vessels, hair follicles, sweat glands, and other structures. Beneath the dermis lies the hypodermis, which is composed mainly of loose connective and fatty tissues.
Epidermis
The epidermis of thick skin has five layers: stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
Cells
The cells in the different layers of the epidermis originate from basal cells located in the stratum basale, yet the cells of each layer are distinctively different.
Dermis
This stained slide shows the two components of the dermis—the papillary layer and the reticular layer. Both are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Skin Pigmentation
The relative coloration of the skin depends of the amount of melanin produced by melanocytes in the stratum basale and taken up by keratinocytes.
Moles
Moles range from benign accumulations of melanocytes to melanomas. These structures populate the landscape of our skin.
Vitiligo
Individuals with vitiligo experience depigmentation that results in lighter colored patches of skin. The condition is especially noticeable on darker skin.
Hair
Hair follicles originate in the epidermis and have many different parts.
Nails
The nail is an accessory structure of the integumentary system.
Eccrine Gland
Eccrine glands are coiled glands in the dermis that release sweat that is mostly water.
Thermoregulation
During strenuous physical activities, such as skiing (a) or running (c), the dermal blood vessels dilate and sweat secretion increases (b). These mechanisms prevent the body from overheating. In contrast, the dermal blood vessels constrict to minimize heat loss in response to low temperatures (b)
Acne
Acne is a result of over-productive sebaceous glands, which leads to formation of blackheads and inflammation of the skin.
Brain
The cranium completely surrounds and protects the brain from non-traumatic injury.
Bones are classified according to their shape.
Long Bone
A typical long bone shows the gross anatomical characteristics of bone.
Periosteum
Endosteum
The periosteum forms the outer surface of bone, and the endosteum lines the medullary cavity.
Flat Bone
This cross-section of a flat bone shows the spongy bone (diploë) lined on either side by a layer of compact bone.
Bone
The surface features of bones depend on their function, location, attachment of ligaments and tendons, or the penetration of blood vessels and nerves.
Bone Cells
Four types of cells are found within bone tissue. Osteogenic cells are undifferentiated and develop into osteoblasts. When osteoblasts get trapped within the calcified matrix, their structure and function changes, and they become osteocytes. Osteoclasts develop from monocytes and macrophages and differ in appearance from other bone cells.
(a) This cross-sectional view of compact bone shows the basic structural unit, the osteon. (b) In this micrograph of the osteon, you can clearly see the concentric lamellae and central canals.
Spongy Bone
Spongy bone is composed of trabeculae that contain the osteocytes. Red marrow fills the spaces in some bones.
Paget's Disease
Normal leg bones are relatively straight, but those affected by Paget’s disease are porous and curved.
Diagram of Blood and Nerve Supply to Bone
Diagram of Blood
Nerve Supply to Bone
Blood vessels and nerves enter the bone through the nutrient foramen.
Intramembranous Ossification
Intramembranous ossification follows four steps. (a) Mesenchymal cells group into clusters, and ossification centers form. (b) Secreted osteoid traps osteoblasts, which then become osteocytes. (c) Trabecular matrix and periosteum form. (d) Compact bone develops superficial to the trabecular bone, and crowded blood vessels condense into red marrow.
Endochondral Ossification
Endochondral ossification follows five steps. (a) Mesenchymal cells differentiate into chondrocytes. (b) The cartilage model of the future bony skeleton and the perichondrium form. (c) Capillaries penetrate cartilage. Perichondrium transforms into periosteum. Periosteal collar develops. Primary ossification center develops. (d) Cartilage and chondrocytes continue to grow at ends of the bone. (e) Secondary ossification centers develop. (f) Cartilage remains at epiphyseal (growth) plate and at joint surface as articular cartilage.
Longitudinal Bone
The epiphyseal plate is responsible for longitudinal bone growth.
Progression from Epiphyseal Plate to Epiphyseal Line
Epiphyseal Plate
Epiphyseal Line
As a bone matures, the epiphyseal plate progresses to an epiphyseal line. (a) Epiphyseal plates are visible in a growing bone. (b) Epiphyseal lines are the remnants of epiphyseal plates in a mature bone.
Fractures
Compare healthy bone with different types of fractures: (a) closed fracture, (b) open fracture, (c) transverse fracture, (d) spiral fracture, (e) comminuted fracture, (f) impacted fracture, (g) greenstick fracture, and (h) oblique fracture.
Fracture
The healing of a bone fracture follows a series of progressive steps: (a) A fracture hematoma forms. (b) Internal and external calli form. (c) Cartilage of the calli is replaced by trabecular bone. (d) Remodeling occurs.
Synthesis
Vitamin D
Graph Showing Relationship Between Age and Bone Mass
Age
Bone Mass
Bone density peaks at about 30 years of age. Women lose bone mass more rapidly than men.
Calcium Homeostasis
The body regulates calcium homeostasis with two pathways; one is signaled to turn on when blood calcium levels drop below normal and one is the pathway that is signaled to turn on when blood calcium levels are elevated.
Axial
Appendicular Skeleton
The axial skeleton supports the head, neck, back, and chest and thus forms the vertical axis of the body. It consists of the skull, vertebral column (including the sacrum and coccyx), and the thoracic cage, formed by the ribs and sternum. The appendicular skeleton is made up of all bones of the upper and lower limbs.
Skull
The skull consists of the rounded brain case that houses the brain and the facial bones that form the upper and lower jaws, nose, orbits, and other facial structures.
An anterior view of the skull shows the bones that form the forehead, orbits (eye sockets), nasal cavity, nasal septum, and upper and lower jaws.
The lateral skull shows the large rounded brain case, zygomatic arch, and the upper and lower jaws. The zygomatic arch is formed jointly by the zygomatic process of the temporal bone and the temporal process of the zygomatic bone. The shallow space above the zygomatic arch is the temporal fossa. The space inferior to the zygomatic arch and deep to the posterior mandible is the infratemporal fossa.
Cranial Fossae
The bones of the brain case surround and protect the brain, which occupies the cranial cavity. The base of the brain case, which forms the floor of cranial cavity, is subdivided into the shallow anterior cranial fossa, the middle cranial fossa, and the deep posterior cranial fossa.
A lateral view of the isolated temporal bone shows the squamous, mastoid, and zygomatic portions of the temporal bone.
External and Internal Views of Base of Skull
(a) The hard palate is formed anteriorly by the palatine processes of the maxilla bones and posteriorly by the horizontal plate of the palatine bones. (b) The complex floor of the cranial cavity is formed by the frontal, ethmoid, sphenoid, temporal, and occipital bones. The lesser wing of the sphenoid bone separates the anterior and middle cranial fossae. The petrous ridge (petrous portion of temporal bone) separates the middle and posterior cranial fossae.
This view of the posterior skull shows attachment sites for muscles and joints that support the skull.
Shown in isolation in (a) superior and (b) posterior views, the sphenoid bone is a single midline bone that forms the anterior walls and floor of the middle cranial fossa. It has a pair of lesser wings and a pair of greater wings. The sella turcica surrounds the hypophyseal fossa. Projecting downward are the medial and lateral pterygoid plates. The sphenoid has multiple openings for the passage of nerves and blood vessels, including the optic canal, superior orbital fissure, foramen rotundum, foramen ovale, and foramen spinosum.
This midline view of the sagittally sectioned skull shows the nasal septum.
Ethmoid Bone
The unpaired ethmoid bone is located at the midline within the central skull. It has an upward projection, the crista galli, and a downward projection, the perpendicular plate, which forms the upper nasal septum. The cribriform plates form both the roof of the nasal cavity and a portion of the anterior cranial fossa floor. The lateral sides of the ethmoid bone form the lateral walls of the upper nasal cavity, part of the medial orbit wall, and give rise to the superior and middle nasal conchae. The ethmoid bone also contains the ethmoid air cells.
Lateral Wall
Nasal Cavity
The three nasal conchae are curved bones that project from the lateral walls of the nasal cavity. The superior nasal concha and middle nasal concha are parts of the ethmoid bone. The inferior nasal concha is an independent bone of the sku
Maxillary Bone
The maxillary bone forms the upper jaw and supports the upper teeth. Each maxilla also forms the lateral floor of each orbit and the majority of the hard palate.
Isolated Mandible
The mandible is the only moveable bone of the skull.
Seven skull bones contribute to the walls of the orbit. Opening into the posterior orbit from the cranial cavity are the optic canal and superior orbital fissure.
Nasal Septum
The nasal septum is formed by the perpendicular plate of the ethmoid bone and the vomer bone. The septal cartilage fills the gap between these bones and extends into the nose.
Paranasal Sinuses
The paranasal sinuses are hollow, air-filled spaces named for the skull bone that each occupies. The most anterior is the frontal sinus, located in the frontal bone above the eyebrows. The largest are the maxillary sinuses, located in the right and left maxillary bones below the orbits. The most posterior is the sphenoid sinus, located in the body of the sphenoid bone, under the sella turcica. The ethmoid air cells are multiple small spaces located in the right and left sides of the ethmoid bone, between the medial wall of the orbit and lateral wall of the upper nasal cavity.
Hyoid Bone
The hyoid bone is located in the upper neck and does not join with any other bone. It provides attachments for muscles that act on the tongue, larynx, and pharynx.
Vertebral Column
The adult vertebral column consists of 24 vertebrae, plus the sacrum and coccyx. The vertebrae are divided into three regions: cervical C1–C7 vertebrae, thoracic T1–T12 vertebrae, and lumbar L1–L5 vertebrae. The vertebral column is curved, with two primary curvatures (thoracic and sacrococcygeal curves) and two secondary curvatures (cervical and lumbar curves).
Abnormal Curvatures of the Vertebral Column
Abnormal Curvatures
(a) Scoliosis is an abnormal lateral bending of the vertebral column. (b) An excessive curvature of the upper thoracic vertebral column is called kyphosis. (c) Lordosis is an excessive curvature in the lumbar region of the vertebral column.
Osteoporosis
Osteoporosis is an age-related disorder that causes the gradual loss of bone density and strength. When the thoracic vertebrae are affected, there can be a gradual collapse of the vertebrae. This results in kyphosis, an excessive curvature of the thoracic region.
Typical Vertebra
A typical vertebra consists of a body and a vertebral arch. The arch is formed by the paired pedicles and paired laminae. Arising from the vertebral arch are the transverse, spinous, superior articular, and inferior articular processes. The vertebral foramen provides for passage of the spinal cord. Each spinal nerve exits through an intervertebral foramen, located between adjacent vertebrae. Intervertebral discs unite the bodies of adjacent vertebrae.
Intervertebral
The bodies of adjacent vertebrae are separated and united by an intervertebral disc, which provides padding and allows for movements between adjacent vertebrae. The disc consists of a fibrous outer layer called the anulus fibrosus and a gel-like center called the nucleus pulposus. The intervertebral foramen is the opening formed between adjacent vertebrae for the exit of a spinal nerve.
Cervical Vertebrae
A typical cervical vertebra has a small body, a bifid spinous process, transverse processes that have a transverse foramen and are curved for spinal nerve passage. The atlas (C1 vertebra) does not have a body or spinous process. It consists of an anterior and a posterior arch and elongated transverse processes. The axis (C2 vertebra) has the upward projecting dens, which articulates with the anterior arch of the atlas.
Thoracic Vertebrae
A typical thoracic vertebra is distinguished by the spinous process, which is long and projects downward to overlap the next inferior vertebra. It also has articulation sites (facets) on the vertebral body and a transverse process for rib attachment.
Lumbar Vertebrae
Lumbar vertebrae are characterized by having a large, thick body and a short, rounded spinous process.
Sacrum
Coccyx
The sacrum is formed from the fusion of five sacral vertebrae, whose lines of fusion are indicated by the transverse ridges. The fused spinous processes form the median sacral crest, while the lateral sacral crest arises from the fused transverse processes. The coccyx is formed by the fusion of four small coccygeal vertebrae.
Weakening of the anulus fibrosus can result in herniation (protrusion) of the nucleus pulposus and compression of a spinal nerve, resulting in pain and/or muscle weakness in the body regions supplied by that nerve.
Ligaments
The anterior longitudinal ligament runs the length of the vertebral column, uniting the anterior sides of the vertebral bodies. The supraspinous ligament connects the spinous processes of the thoracic and lumbar vertebrae. In the posterior neck, the supraspinous ligament enlarges to form the nuchal ligament, which attaches to the cervical spinous processes and to the base of the skull.
Rib Articulation
Thoracic vertebrae have superior and inferior articular facets on the vertebral body for articulation with the head of a rib, and a transverse process facet for articulation with the rib tubercle.
Thoracic Cage
The thoracic cage is formed by the (a) sternum and (b) 12 pairs of ribs with their costal cartilages. The ribs are anchored posteriorly to the 12 thoracic vertebrae. The sternum consists of the manubrium, body, and xiphoid process. The ribs are classified as true ribs (1–7) and false ribs (8–12). The last two pairs of false ribs are also known as floating ribs (11–12).
Newborn Skull
The bones of the newborn skull are not fully ossified and are separated by large areas called fontanelles, which are filled with fibrous connective tissue. The fontanelles allow for continued growth of the skull after birth. At the time of birth, the facial bones are small and underdeveloped, and the mastoid process has not yet formed.
Pectoral Girdle
The pectoral girdle consists of the clavicle and the scapula, which serve to attach the upper limb to the sternum of the axial skeleton.
Scapula
The isolated scapula is shown here from its anterior (deep) side and its posterior (superficial) side.
Humerus
Elbow Joint
The humerus is the single bone of the upper arm region. It articulates with the radius and ulna bones of the forearm to form the elbow joint.
Ulna
Radius
The ulna is located on the medial side of the forearm, and the radius is on the lateral side. These bones are attached to each other by an interosseous membrane.
Wrist
Hand
The eight carpal bones form the base of the hand. These are arranged into proximal and distal rows of four bones each. The metacarpal bones form the palm of the hand. The thumb and fingers consist of the phalanx bones.
This radiograph shows the position of the bones within the hand. Note the carpal bones that form the base of the hand
Carpal Tunnel
The carpal tunnel is the passageway by which nine muscle tendons and a major nerve enter the hand from the anterior forearm. The walls and floor of the carpal tunnel are formed by the U-shaped grouping of the carpal bones, and the roof is formed by the flexor retinaculum, a strong ligament that anteriorly unites the bones.
During tight gripping—compare (b) to (a)—the fourth and, particularly, the fifth metatarsal bones are pulled anteriorly. This increases the contact between the object and the medial side of the hand, thus improving the firmness of the grip.
Falls or direct blows can result in fractures of the surgical neck or shaft of the humerus. Falls onto the elbow can fracture the distal humerus. A Colles fracture of the distal radius is the most common forearm fracture.
Pelvis
The pelvic girdle is formed by a single hip bone. The hip bone attaches the lower limb to the axial skeleton through its articulation with the sacrum. The right and left hip bones, plus the sacrum and the coccyx, together form the pelvis.
The adult hip bone consists of three regions. The ilium forms the large, fan-shaped superior portion, the ischium forms the posteroinferior portion, and the pubis forms the anteromedial portion.
The posterior sacroiliac ligament supports the sacroiliac joint. The sacrospinous ligament spans the sacrum to the ischial spine, and the sacrotuberous ligament spans the sacrum to the ischial tuberosity. The sacrospinous and sacrotuberous ligaments contribute to the formation of the greater and lesser sciatic foramens.
Male
Female
The female pelvis is adapted for childbirth and is broader, with a larger subpubic angle, a rounder pelvic brim, and a wider and more shallow lesser pelvic cavity than the male pelvis.
Femur
Patella
The femur is the single bone of the thigh region. It articulates superiorly with the hip bone at the hip joint, and inferiorly with the tibia at the knee joint. The patella only articulates with the distal end of the femur.
Q-Angle
The Q-angle is a measure of the amount of lateral deviation of the femur from the vertical line of the tibia. Adult females have a larger Q-angle due to their wider pelvis than adult males.
Tibia
Fibula
The tibia is the larger, weight-bearing bone located on the medial side of the leg. The fibula is the slender bone of the lateral side of the leg and does not bear weight.
Foot
The bones of the foot are divided into three groups. The posterior foot is formed by the seven tarsal bones. The mid-foot has the five metatarsal bones. The toes contain the phalanges.
Embryo
Limb buds are visible in an embryo at the end of the seventh week of development (embryo derived from an ectopic pregnancy)
Clubfoot
Clubfoot This photograph shows a baby with a clubfoot.Clubfoot is a common deformity of the ankle and foot that is present at birth. Most cases are corrected without surgery, and affected individuals will grow up to lead normal, active lives. (credit: James W. Hanson)
The suture joints of the skull are an example of a synarthrosis, an immobile or essentially immobile joint.
Multiaxial Joint
A multiaxial joint, such as the hip joint, allows for three types of movement: anterior-posterior, medial-lateral, and rotational.
Joints
Fibrous joints form strong connections between bones. (a) Sutures join most bones of the skull. (b) An interosseous membrane forms a syndesmosis between the radius and ulna bones of the forearm. (c) A gomphosis is a specialized fibrous joint that anchors a tooth to its socket in the jaw.
The fontanelles of a newborn’s skull are broad areas of fibrous connective tissue that form fibrous joints between the bones of the skull.
Synovial Joints
Synovial joints allow for smooth movements between the adjacent bones. The joint is surrounded by an articular capsule that defines a joint cavity filled with synovial fluid. The articulating surfaces of the bones are covered by a thin layer of articular cartilage. Ligaments support the joint by holding the bones together and resisting excess or abnormal joint motions.
Bursae
Bursae are fluid-filled sacs that serve to prevent friction between skin, muscle, or tendon and an underlying bone. Three major bursae and a fat pad are part of the complex joint that unites the femur and tibia of the leg.
The six types of synovial joints allow the body to move in a variety of ways. (a) Pivot joints allow for rotation around an axis, such as between the first and second cervical vertebrae, which allows for side-to-side rotation of the head. (b) The hinge joint of the elbow works like a door hinge. (c) The articulation between the trapezium carpal bone and the first metacarpal bone at the base of the thumb is a saddle joint. (d) Plane joints, such as those between the tarsal bones of the foot, allow for limited gliding movements between bones. (e) The radiocarpal joint of the wrist is a condyloid joint. (f) The hip and shoulder joints are the only ball-and-socket joints of the body.
Osteoarthritis
Osteoarthritis of a synovial joint results from aging or prolonged joint wear and tear. These cause erosion and loss of the articular cartilage covering the surfaces of the bones, resulting in inflammation that causes joint stiffness and pain.
Movements
Synovial joints give the body many ways in which to move. (a)–(b) Flexion and extension motions are in the sagittal (anterior–posterior) plane of motion. These movements take place at the shoulder, hip, elbow, knee, wrist, metacarpophalangeal, metatarsophalangeal, and interphalangeal joints. (c)–(d) Anterior bending of the head or vertebral column is flexion, while any posterior-going movement is extension. (e) Abduction and adduction are motions of the limbs, hand, fingers, or toes in the coronal (medial–lateral) plane of movement. Moving the limb or hand laterally away from the body, or spreading the fingers or toes, is abduction. Adduction brings the limb or hand toward or across the midline of the body, or brings the fingers or toes together. Circumduction is the movement of the limb, hand, or fingers in a circular pattern, using the sequential combination of flexion, adduction, extension, and abduction motions. Adduction/abduction and circumduction take place at the shoulder, hip, wrist, metacarpophalangeal, and metatarsophalangeal joints. (f) Turning of the head side to side or twisting of the body is rotation. Medial and lateral rotation of the upper limb at the shoulder or lower limb at the hip involves turning the anterior surface of the limb toward the midline of the body (medial or internal rotation) or away from the midline (lateral or external rotation).
(g) Supination of the forearm turns the hand to the palm forward position in which the radius and ulna are parallel, while forearm pronation turns the hand to the palm backward position in which the radius crosses over the ulna to form an "X." (h) Dorsiflexion of the foot at the ankle joint moves the top of the foot toward the leg, while plantar flexion lifts the heel and points the toes. (i) Eversion of the foot moves the bottom (sole) of the foot away from the midline of the body, while foot inversion faces the sole toward the midline. (j) Protraction of the mandible pushes the chin forward, and retraction pulls the chin back. (k) Depression of the mandible opens the mouth, while elevation closes it. (l) Opposition of the thumb brings the tip of the thumb into contact with the tip of the fingers of the same hand and reposition brings the thumb back next to the index finger.
Atlantoaxial Joint
The atlantoaxial joint is a pivot type of joint between the dens portion of the axis (C2 vertebra) and the anterior arch of the atlas (C1 vertebra), with the dens held in place by a ligament.
Temporomandibular Joint
The temporomandibular joint is the articulation between the temporal bone of the skull and the condyle of the mandible, with an articular disc located between these bones. During depression of the mandible (opening of the mouth), the mandibular condyle moves both forward and hinges downward as it travels from the mandibular fossa onto the articular tubercle.
Glenohumeral Joint
The glenohumeral (shoulder) joint is a ball-and-socket joint that provides the widest range of motions. It has a loose articular capsule and is supported by ligaments and the rotator cuff muscles.
(a) The elbow is a hinge joint that allows only for flexion and extension of the forearm. (b) It is supported by the ulnar and radial collateral ligaments. (c) The annular ligament supports the head of the radius at the proximal radioulnar joint, the pivot joint that allows for rotation of the radius.
Hip Joint
(a) The ball-and-socket joint of the hip is a multiaxial joint that provides both stability and a wide range of motion. (b–c) When standing, the supporting ligaments are tight, pulling the head of the femur into the acetabulum.
Knee Joint
(a) The knee joint is the largest joint of the body. (b)–(c) It is supported by the tibial and fibular collateral ligaments located on the sides of the knee outside of the articular capsule, and the anterior and posterior cruciate ligaments found inside the capsule. The medial and lateral menisci provide padding and support between the femoral condyles and tibial condyles.
Knee Injury
A strong blow to the lateral side of the extended knee will cause three injuries, in sequence: tearing of the tibial collateral ligament, damage to the medial meniscus, and rupture of the anterior cruciate ligament.
Ankle Joint
The talocrural (ankle) joint is a uniaxial hinge joint that only allows for dorsiflexion or plantar flexion of the foot. Movements at the subtalar joint, between the talus and calcaneus bones, combined with motions at other intertarsal joints, enables eversion/inversion movements of the foot. Ligaments that unite the medial or lateral malleolus with the talus and calcaneus bones serve to support the talocrural joint and to resist excess eversion or inversion of the foot.
Muscle Tissue
The body contains three types of muscle tissue: (a) skeletal muscle, (b) smooth muscle, and (c) cardiac muscle.
Connective Tissue
Bundles of muscle fibers, called fascicles, are covered by the perimysium. Muscle fibers are covered by the endomysium.
Muscle Fiber
A skeletal muscle fiber is surrounded by a plasma membrane called the sarcolemma, which contains sarcoplasm, the cytoplasm of muscle cells. A muscle fiber is composed of many fibrils, which give the cell its striated appearance.
Sarcomere
The sarcomere, the region from one Z-line to the next Z-line, is the functional unit of a skeletal muscle fiber.
Motor End-Plate
Innervation
At the NMJ, the axon terminal releases ACh. The motor end-plate is the location of the ACh-receptors in the muscle fiber sarcolemma. When ACh molecules are released, they diffuse across a minute space called the synaptic cleft and bind to the receptors.
T-tubule
Narrow T-tubules permit the conduction of electrical impulses. The SR functions to regulate intracellular levels of calcium. Two terminal cisternae (where enlarged SR connects to the T-tubule) and one T-tubule comprise a triad—a “threesome” of membranes, with those of SR on two sides and the T-tubule sandwiched between them.
A cross-bridge forms between actin and the myosin heads triggering contraction. As long as Ca++ ions remain in the sarcoplasm to bind to troponin, and as long as ATP is available, the muscle fiber will continue to shorten.
Ca++ ions are pumped back into the SR, which causes the tropomyosin to reshield the binding sites on the actin strands. A muscle may also stop contracting when it runs out of ATP and becomes fatigued.
The Sliding Filament Model of Muscle Contraction
Muscle Contraction
Filament
When a sarcomere contracts, the Z lines move closer together, and the I band becomes smaller. The A band stays the same width. At full contraction, the thin and thick filaments overlap completely.
Skeletal Muscle Contraction
(a) The active site on actin is exposed as calcium binds to troponin. (b) The myosin head is attracted to actin, and myosin binds actin at its actin-binding site, forming the cross-bridge. (c) During the power stroke, the phosphate generated in the previous contraction cycle is released. This results in the myosin head pivoting toward the center of the sarcomere, after which the attached ADP and phosphate group are released. (d) A new molecule of ATP attaches to the myosin head, causing the cross-bridge to detach. (e) The myosin head hydrolyzes ATP to ADP and phosphate, which returns the myosin to the cocked position.
Muscle Metabolism
(a) Some ATP is stored in a resting muscle. As contraction starts, it is used up in seconds. More ATP is generated from creatine phosphate for about 15 seconds. (b) Each glucose molecule produces two ATP and two molecules of pyruvic acid, which can be used in aerobic respiration or converted to lactic acid. If oxygen is not available, pyruvic acid is converted to lactic acid, which may contribute to muscle fatigue. This occurs during strenuous exercise when high amounts of energy are needed but oxygen cannot be sufficiently delivered to muscle. (c) Aerobic respiration is the breakdown of glucose in the presence of oxygen (O2) to produce carbon dioxide, water, and ATP. Approximately 95 percent of the ATP required for resting or moderately active muscles is provided by aerobic respiration, which takes place in mitochondria.
Muscle Contractions
During isotonic contractions, muscle length changes to move a load. During isometric contractions, muscle length does not change because the load exceeds the tension the muscle can generate.
Atrophy
Muscle mass is reduced as muscles atrophy with disuse.
Cardiac Muscle
Intercalated discs are part of the cardiac muscle sarcolemma and they contain gap junctions and desmosomes.
Smooth Muscle Tissue
Smooth muscle tissue is found around organs in the digestive, respiratory, reproductive tracts and the iris of the eye.
The dense bodies and intermediate filaments are networked through the sarcoplasm, which cause the muscle fiber to contract.
Motor Units
A series of axon-like swelling, called varicosities or “boutons,” from autonomic neurons form motor units through the smooth muscle.
Prime Movers
Synergists
The biceps brachii flex the lower arm. The brachoradialis, in the forearm, and brachialis, located deep to the biceps in the upper arm, are both synergists that aid in this motion.
Muscle Shapes
Fiber Alignment
The skeletal muscles of the body typically come in seven different general shapes.
Muscular System
On the anterior and posterior views of the muscular system above, superficial muscles (those at the surface) are shown on the right side of the body while deep muscles (those underneath the superficial muscles) are shown on the left half of the body. For the legs, superficial muscles are shown in the anterior view while the posterior view shows both superficial and deep muscles.
Muscles
Many of the muscles of facial expression insert into the skin surrounding the eyelids, nose and mouth, producing facial expressions by moving the skin rather than bones.
Nose
Several bones that help form the walls of the nasal cavity have air-containing spaces called the paranasal sinuses, which serve to warm and humidify incoming air. Sinuses are lined with a mucosa. Each paranasal sinus is named for its associated bone: frontal sinus, maxillary sinus, sphenoidal sinus, and ethmoidal sinus. The sinuses produce mucus and lighten the weight of the skull.
Suturing
In this video, I demonstrate the surgeon's knot and the square knot and give some general beginner tips on how to suture.
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