610 Medicine & Health

Clinical Procedures for Safer Patient Care

This peer reviewed e-book is a must-read for nurses and other health professionals who strive to teach with creativity and excellence in clinical settings. Each chapter presents current evidence informed educational practice knowledge. Each topic is…

Metastatic Extramammary Paget's Disease: Pathogenesis and Novel Therapeutic Approach

Extramammary Paget's disease (EMPD) is a rare, slow-growing, cutaneous adenocarcinoma that usually originates in the anogenital area and axillae outside the mammary glands. EMPD mostly progresses slowly and is often diagnosed as carcinoma in situ;…

Head and Neck Cancers

1. A variety of different malignancies fall into the category of “Head and. Neck Cancers”. This chapter focuses on upper aerodigestive tract cancer.
2. Tobacco and alcohol use and human papillomavirus infection are
common causes of head and…

Introduction to Genetic Disorders

This is the first lecture in the Bioinformatics of Genomic Medicine 2017 workshop hosted by the Canadian Bioinformatics Workshops. This lecture is by Michael Brudno from the Hospital for Sick Children.
For tutorials and lecture slides for this…

Food as Medicine: Preventing and Treating the Most Common Diseases with Diet

This is Dr. Greger's 2015 live presentation. Dr. Greger has scoured the world's scholarly literature on clinical nutrition and developed this new presentation based on the latest in cutting-edge research exploring the role diet may play in…

Pharmacokinetics/ADME Of Drugs | Pharmacology Online Lecture-1 | For Upcoming D.Pharm & B.Pharm Exam

In this video , we have discussed about PHARMACOKINETICS OF DRUGS - ABSORPTION, DISTRIBUTION, METABOLISM, EXCRETION (ADME) IN BRIEF. Watch the video till the end to get complete information regarding pharmacokinetics of drugs.
Topic discussed in the…

Principles of Nutrition Textbook

As we get started on our journey into the world of health and nutrition, our first focus will be to
demonstrate that nutritional science is an evolving field of study, continually being updated and
supported by research, studies, and trials.

Cancer of the Esophagus

This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents an overview of esophageal cancer, including etiology, epidemiology, screening, pathology, staging, and treatment.

Coming Off Psychiatric Drugs: A Harm Reduction Approach to Medication Withdrawal | Will Hall

Psychiatric medications can sometimes be very useful, but there is often little information or guidance when the risks and harm start to outweigh the benefits. Will Hall provides an introductory overview of how to come off psychiatric medication.…

Drug Formulations

This is a tutorial/lecture on Drug Formulations. We cover some topics important for classes such as Biochemistry and Pharmacology.

Breast Cancer Eliminated Using Keshe Technologies - Demo by Dr.Rodrigo Vildosola

Dr. Rodrigo Vildosola explains his method for treating breast cancer using Keshe Plasma Technologies. He gives an example of how he used this with one of his patients with stunning results.
Warning: The video contains graphic images of a medical…

Introduction to Cancer Genomics

This is the first lecture in the Bioinformatics for Cancer Genomics 2017 workshop hosted by the Canadian Bioinformatics Workshops. This lecture is by Trevor Pugh from the Princess Margaret Cancer Centre.
For tutorials and lecture slides for this…

MCQs in Oral and Maxillofacial Surgery - Local and General Anesthetics

Oral and Maxillofacial Surgery MCQs - Local and General Anesthetics
Practice these MCQs for MDS entrance preparation in AIIMS, COMEDK, AIPG, PGI, BHU, etc. Also useful for ADA, NBDE, NDEB and other dental board exams. Please Share and Subscribe to…

Restoring a tooth (Gold Crown) - Part 3

This video shows the final stage of the production of a cast gold crown for a damaged tooth. The gold casting is cooled and removed from the mould. Sand blasting, an acid bath and then a series of abrasive burs are used to trim and finish the casting…

Restoring a tooth (Gold Crown) - Part 2

This video shows the second stage of the production of a cast gold crown for a damaged tooth. The wax template of the tooth is sprued using wax wire, then invested in a refractory investment material. The video shows the mould being heated to both…

Restoring a tooth (Gold Crown) - Part 1

This video shows the first stage of the production of a cast gold crown for a damaged tooth. The crown is made on the model (See Videos 2 and 3) using wax, which will be replaced by molten gold in the lost wax casting process. The technique of making…

Basic Suturing: How to Suture

In this video, I demonstrate the surgeon's knot and the square knot and give some general beginner tips on how to suture.

Hypothalamus and Limbic System - UBC Neuroanatomy - Season 1 - Ep 4

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Middle Mediastinum and Heart - Anatomy and Dissection Guide

The anatomy shown in this video is based off of the UBC MEDD 411 gross anatomy checklist.

Foundations for Assisting in Home Care

Home health services are those which are provided within the comforts of the home setting to help people avoid hospitalization or skilled nursing facility placement while they recover from illness, injury, or disability. Home health care may also be…

Urogynaecology Textbook

The field of Urogynaecology has expanded dramatically over the past decade with the advent of a number of new medical and surgical treatment modalities. The evidence base on pelvic floor dysfunction has also grown extensively. This multi-contributor…

Kansas State University Human Nutrition Flexbook

The CK-12 foundation defines a flexbook as a “free and open source textbook platform where
one can build and edit collaborative textbooks1
.” The FNDH 400 (formerly HN 400, department
changed its name from Human Nutrition to Food, Nutrition,…

The Nose and its Adjacent Structures

Several bones that help form the walls of the nasal cavity have air-containing spaces called the paranasal sinuses, which serve to warm and humidify incoming air. Sinuses are lined with a mucosa. Each paranasal sinus is named for its associated bone:…

Muscles of Facial Expression

Many of the muscles of facial expression insert into the skin surrounding the eyelids, nose and mouth, producing facial expressions by moving the skin rather than bones.

Overview of the Muscular System

On the anterior and posterior views of the muscular system above, superficial muscles (those at the surface) are shown on the right side of the body while deep muscles (those underneath the superficial muscles) are shown on the left half of the body.…

Muscle Shapes and Fiber Alignment

The skeletal muscles of the body typically come in seven different general shapes.

Prime Movers and Synergists

The biceps brachii flex the lower arm. The brachoradialis, in the forearm, and brachialis, located deep to the biceps in the upper arm, are both synergists that aid in this motion.

Motor Units

A series of axon-like swelling, called varicosities or “boutons,” from autonomic neurons form motor units through the smooth muscle.

Muscle Contraction

The dense bodies and intermediate filaments are networked through the sarcoplasm, which cause the muscle fiber to contract.

Smooth Muscle Tissue

Smooth muscle tissue is found around organs in the digestive, respiratory, reproductive tracts and the iris of the eye.

Cardiac Muscle

Intercalated discs are part of the cardiac muscle sarcolemma and they contain gap junctions and desmosomes.

Atrophy

Muscle mass is reduced as muscles atrophy with disuse.

Types of Muscle Contractions

During isotonic contractions, muscle length changes to move a load. During isometric contractions, muscle length does not change because the load exceeds the tension the muscle can generate.

Muscle Metabolism

(a) Some ATP is stored in a resting muscle. As contraction starts, it is used up in seconds. More ATP is generated from creatine phosphate for about 15 seconds. (b) Each glucose molecule produces two ATP and two molecules of pyruvic acid, which can…

Skeletal Muscle Contraction

(a) The active site on actin is exposed as calcium binds to troponin. (b) The myosin head is attracted to actin, and myosin binds actin at its actin-binding site, forming the cross-bridge. (c) During the power stroke, the phosphate generated in the…

The Sliding Filament Model of Muscle Contraction

When a sarcomere contracts, the Z lines move closer together, and the I band becomes smaller. The A band stays the same width. At full contraction, the thin and thick filaments overlap completely.

Relaxation of a Muscle Fiber

Ca++ ions are pumped back into the SR, which causes the tropomyosin to reshield the binding sites on the actin strands. A muscle may also stop contracting when it runs out of ATP and becomes fatigued.

Contraction of a Muscle Fiber

A cross-bridge forms between actin and the myosin heads triggering contraction. As long as Ca++ ions remain in the sarcoplasm to bind to troponin, and as long as ATP is available, the muscle fiber will continue to shorten.

The T-tubule

Narrow T-tubules permit the conduction of electrical impulses. The SR functions to regulate intracellular levels of calcium. Two terminal cisternae (where enlarged SR connects to the T-tubule) and one T-tubule comprise a triad—a “threesome” of…

Motor End-Plate and Innervation

At the NMJ, the axon terminal releases ACh. The motor end-plate is the location of the ACh-receptors in the muscle fiber sarcolemma. When ACh molecules are released, they diffuse across a minute space called the synaptic cleft and bind to the…

The Sarcomere

The sarcomere, the region from one Z-line to the next Z-line, is the functional unit of a skeletal muscle fiber.

Muscle Fiber

A skeletal muscle fiber is surrounded by a plasma membrane called the sarcolemma, which contains sarcoplasm, the cytoplasm of muscle cells. A muscle fiber is composed of many fibrils, which give the cell its striated appearance.

The Three Connective Tissue Layers

Bundles of muscle fibers, called fascicles, are covered by the perimysium. Muscle fibers are covered by the endomysium.

The Three Types of Muscle Tissue

The body contains three types of muscle tissue: (a) skeletal muscle, (b) smooth muscle, and (c) cardiac muscle.

Ankle Joint

The talocrural (ankle) joint is a uniaxial hinge joint that only allows for dorsiflexion or plantar flexion of the foot. Movements at the subtalar joint, between the talus and calcaneus bones, combined with motions at other intertarsal joints,…

Knee Injury

A strong blow to the lateral side of the extended knee will cause three injuries, in sequence: tearing of the tibial collateral ligament, damage to the medial meniscus, and rupture of the anterior cruciate ligament.

Knee Joint

(a) The knee joint is the largest joint of the body. (b)–(c) It is supported by the tibial and fibular collateral ligaments located on the sides of the knee outside of the articular capsule, and the anterior and posterior cruciate ligaments found…

Hip Joint

(a) The ball-and-socket joint of the hip is a multiaxial joint that provides both stability and a wide range of motion. (b–c) When standing, the supporting ligaments are tight, pulling the head of the femur into the acetabulum.

Elbow Joint

(a) The elbow is a hinge joint that allows only for flexion and extension of the forearm. (b) It is supported by the ulnar and radial collateral ligaments. (c) The annular ligament supports the head of the radius at the proximal radioulnar joint, the…

Glenohumeral Joint

The glenohumeral (shoulder) joint is a ball-and-socket joint that provides the widest range of motions. It has a loose articular capsule and is supported by ligaments and the rotator cuff muscles.

Temporomandibular Joint

The temporomandibular joint is the articulation between the temporal bone of the skull and the condyle of the mandible, with an articular disc located between these bones. During depression of the mandible (opening of the mouth), the mandibular…

Atlantoaxial Joint

The atlantoaxial joint is a pivot type of joint between the dens portion of the axis (C2 vertebra) and the anterior arch of the atlas (C1 vertebra), with the dens held in place by a ligament.

Movements of the Body, Part 2

(g) Supination of the forearm turns the hand to the palm forward position in which the radius and ulna are parallel, while forearm pronation turns the hand to the palm backward position in which the radius crosses over the ulna to form an "X." (h)…

Movements of the Body, Part 1

Synovial joints give the body many ways in which to move. (a)–(b) Flexion and extension motions are in the sagittal (anterior–posterior) plane of motion. These movements take place at the shoulder, hip, elbow, knee, wrist, metacarpophalangeal,…

Osteoarthritis

Osteoarthritis of a synovial joint results from aging or prolonged joint wear and tear. These cause erosion and loss of the articular cartilage covering the surfaces of the bones, resulting in inflammation that causes joint stiffness and pain.

Types of Synovial Joints

The six types of synovial joints allow the body to move in a variety of ways. (a) Pivot joints allow for rotation around an axis, such as between the first and second cervical vertebrae, which allows for side-to-side rotation of the head. (b) The…

Bursae

Bursae are fluid-filled sacs that serve to prevent friction between skin, muscle, or tendon and an underlying bone. Three major bursae and a fat pad are part of the complex joint that unites the femur and tibia of the leg.

Synovial Joints

Synovial joints allow for smooth movements between the adjacent bones. The joint is surrounded by an articular capsule that defines a joint cavity filled with synovial fluid. The articulating surfaces of the bones are covered by a thin layer of…

The Newborn Skull

The fontanelles of a newborn’s skull are broad areas of fibrous connective tissue that form fibrous joints between the bones of the skull.

Fibrous Joints

Fibrous joints form strong connections between bones. (a) Sutures join most bones of the skull. (b) An interosseous membrane forms a syndesmosis between the radius and ulna bones of the forearm. (c) A gomphosis is a specialized fibrous joint that…

Multiaxial Joint

A multiaxial joint, such as the hip joint, allows for three types of movement: anterior-posterior, medial-lateral, and rotational.

Suture Joints of Skull

The suture joints of the skull are an example of a synarthrosis, an immobile or essentially immobile joint.

Clubfoot

Clubfoot
This photograph shows a baby with a clubfoot.Clubfoot is a common deformity of the ankle and foot that is present at birth. Most cases are corrected without surgery, and affected individuals will grow up to lead normal, active lives.…

Embryo at Seven Weeks

Limb buds are visible in an embryo at the end of the seventh week of development (embryo derived from an ectopic pregnancy)

Bones of the Foot

The bones of the foot are divided into three groups. The posterior foot is formed by the seven tarsal bones. The mid-foot has the five metatarsal bones. The toes contain the phalanges.

Tibia and Fibula

The tibia is the larger, weight-bearing bone located on the medial side of the leg. The fibula is the slender bone of the lateral side of the leg and does not bear weight.

The Q-Angle

The Q-angle is a measure of the amount of lateral deviation of the femur from the vertical line of the tibia. Adult females have a larger Q-angle due to their wider pelvis than adult males.

Femur and Patella

The femur is the single bone of the thigh region. It articulates superiorly with the hip bone at the hip joint, and inferiorly with the tibia at the knee joint. The patella only articulates with the distal end of the femur.

Male and Female Pelvis

The female pelvis is adapted for childbirth and is broader, with a larger subpubic angle, a rounder pelvic brim, and a wider and more shallow lesser pelvic cavity than the male pelvis.

Ligaments of the Pelvis

The posterior sacroiliac ligament supports the sacroiliac joint. The sacrospinous ligament spans the sacrum to the ischial spine, and the sacrotuberous ligament spans the sacrum to the ischial tuberosity. The sacrospinous and sacrotuberous ligaments…

The Hip Bone

The adult hip bone consists of three regions. The ilium forms the large, fan-shaped superior portion, the ischium forms the posteroinferior portion, and the pubis forms the anteromedial portion.

Pelvis

The pelvic girdle is formed by a single hip bone. The hip bone attaches the lower limb to the axial skeleton through its articulation with the sacrum. The right and left hip bones, plus the sacrum and the coccyx, together form the pelvis.

Fractures of the Humerus and Radius

Falls or direct blows can result in fractures of the surgical neck or shaft of the humerus. Falls onto the elbow can fracture the distal humerus. A Colles fracture of the distal radius is the most common forearm fracture.

Hand During Gripping

During tight gripping—compare (b) to (a)—the fourth and, particularly, the fifth metatarsal bones are pulled anteriorly. This increases the contact between the object and the medial side of the hand, thus improving the firmness of the grip.

Carpal Tunnel

The carpal tunnel is the passageway by which nine muscle tendons and a major nerve enter the hand from the anterior forearm. The walls and floor of the carpal tunnel are formed by the U-shaped grouping of the carpal bones, and the roof is formed by…

Bones of the Hand

This radiograph shows the position of the bones within the hand. Note the carpal bones that form the base of the hand

Bones of the Wrist and Hand

The eight carpal bones form the base of the hand. These are arranged into proximal and distal rows of four bones each. The metacarpal bones form the palm of the hand. The thumb and fingers consist of the phalanx bones.

Ulna and Radius

The ulna is located on the medial side of the forearm, and the radius is on the lateral side. These bones are attached to each other by an interosseous membrane.

Humerus and Elbow Joint

The humerus is the single bone of the upper arm region. It articulates with the radius and ulna bones of the forearm to form the elbow joint.

Scapula

The isolated scapula is shown here from its anterior (deep) side and its posterior (superficial) side.

Pectoral Girdle

The pectoral girdle consists of the clavicle and the scapula, which serve to attach the upper limb to the sternum of the axial skeleton.

Newborn Skull

The bones of the newborn skull are not fully ossified and are separated by large areas called fontanelles, which are filled with fibrous connective tissue. The fontanelles allow for continued growth of the skull after birth. At the time of birth, the…

Thoracic Cage

The thoracic cage is formed by the (a) sternum and (b) 12 pairs of ribs with their costal cartilages. The ribs are anchored posteriorly to the 12 thoracic vertebrae. The sternum consists of the manubrium, body, and xiphoid process. The ribs are…

Rib Articulation in Thoracic Vertebrae

Thoracic vertebrae have superior and inferior articular facets on the vertebral body for articulation with the head of a rib, and a transverse process facet for articulation with the rib tubercle.

Ligaments of Vertebral Column

The anterior longitudinal ligament runs the length of the vertebral column, uniting the anterior sides of the vertebral bodies. The supraspinous ligament connects the spinous processes of the thoracic and lumbar vertebrae. In the posterior neck, the…

Herniated Intervertebral Disc

Weakening of the anulus fibrosus can result in herniation (protrusion) of the nucleus pulposus and compression of a spinal nerve, resulting in pain and/or muscle weakness in the body regions supplied by that nerve.

Sacrum and Coccyx

The sacrum is formed from the fusion of five sacral vertebrae, whose lines of fusion are indicated by the transverse ridges. The fused spinous processes form the median sacral crest, while the lateral sacral crest arises from the fused transverse…

Lumbar Vertebrae

Lumbar vertebrae are characterized by having a large, thick body and a short, rounded spinous process.

Thoracic Vertebrae

A typical thoracic vertebra is distinguished by the spinous process, which is long and projects downward to overlap the next inferior vertebra. It also has articulation sites (facets) on the vertebral body and a transverse process for rib attachment.

Cervical Vertebrae

A typical cervical vertebra has a small body, a bifid spinous process, transverse processes that have a transverse foramen and are curved for spinal nerve passage. The atlas (C1 vertebra) does not have a body or spinous process. It consists of an…

Intervertebral Disc

The bodies of adjacent vertebrae are separated and united by an intervertebral disc, which provides padding and allows for movements between adjacent vertebrae. The disc consists of a fibrous outer layer called the anulus fibrosus and a gel-like…

Parts of a Typical Vertebra

A typical vertebra consists of a body and a vertebral arch. The arch is formed by the paired pedicles and paired laminae. Arising from the vertebral arch are the transverse, spinous, superior articular, and inferior articular processes. The vertebral…

Osteoporosis

Osteoporosis is an age-related disorder that causes the gradual loss of bone density and strength. When the thoracic vertebrae are affected, there can be a gradual collapse of the vertebrae. This results in kyphosis, an excessive curvature of the…

Abnormal Curvatures of the Vertebral Column

(a) Scoliosis is an abnormal lateral bending of the vertebral column. (b) An excessive curvature of the upper thoracic vertebral column is called kyphosis. (c) Lordosis is an excessive curvature in the lumbar region of the vertebral column.

Vertebral Column

The adult vertebral column consists of 24 vertebrae, plus the sacrum and coccyx. The vertebrae are divided into three regions: cervical C1–C7 vertebrae, thoracic T1–T12 vertebrae, and lumbar L1–L5 vertebrae. The vertebral column is curved, with…

Hyoid Bone

The hyoid bone is located in the upper neck and does not join with any other bone. It provides attachments for muscles that act on the tongue, larynx, and pharynx.

Paranasal Sinuses

The paranasal sinuses are hollow, air-filled spaces named for the skull bone that each occupies. The most anterior is the frontal sinus, located in the frontal bone above the eyebrows. The largest are the maxillary sinuses, located in the right and…

Nasal Septum

The nasal septum is formed by the perpendicular plate of the ethmoid bone and the vomer bone. The septal cartilage fills the gap between these bones and extends into the nose.

Bones of the Orbit

Seven skull bones contribute to the walls of the orbit. Opening into the posterior orbit from the cranial cavity are the optic canal and superior orbital fissure.

Isolated Mandible

The mandible is the only moveable bone of the skull.

Maxillary Bone

The maxillary bone forms the upper jaw and supports the upper teeth. Each maxilla also forms the lateral floor of each orbit and the majority of the hard palate.

Lateral Wall of Nasal Cavity

The three nasal conchae are curved bones that project from the lateral walls of the nasal cavity. The superior nasal concha and middle nasal concha are parts of the ethmoid bone. The inferior nasal concha is an independent bone of the sku

Ethmoid Bone

The unpaired ethmoid bone is located at the midline within the central skull. It has an upward projection, the crista galli, and a downward projection, the perpendicular plate, which forms the upper nasal septum. The cribriform plates form both the…

Sagittal Section of Skull

This midline view of the sagittally sectioned skull shows the nasal septum.

Sphenoid Bone

Shown in isolation in (a) superior and (b) posterior views, the sphenoid bone is a single midline bone that forms the anterior walls and floor of the middle cranial fossa. It has a pair of lesser wings and a pair of greater wings. The sella turcica…

Posterior View of Skull

This view of the posterior skull shows attachment sites for muscles and joints that support the skull.

External and Internal Views of Base of Skull

(a) The hard palate is formed anteriorly by the palatine processes of the maxilla bones and posteriorly by the horizontal plate of the palatine bones. (b) The complex floor of the cranial cavity is formed by the frontal, ethmoid, sphenoid, temporal,…

Temporal Bone

A lateral view of the isolated temporal bone shows the squamous, mastoid, and zygomatic portions of the temporal bone.

Cranial Fossae

The bones of the brain case surround and protect the brain, which occupies the cranial cavity. The base of the brain case, which forms the floor of cranial cavity, is subdivided into the shallow anterior cranial fossa, the middle cranial fossa, and…

Lateral View of Skull

The lateral skull shows the large rounded brain case, zygomatic arch, and the upper and lower jaws. The zygomatic arch is formed jointly by the zygomatic process of the temporal bone and the temporal process of the zygomatic bone. The shallow space…

Anterior View of Skull

An anterior view of the skull shows the bones that form the forehead, orbits (eye sockets), nasal cavity, nasal septum, and upper and lower jaws.

Parts of the Skull

The skull consists of the rounded brain case that houses the brain and the facial bones that form the upper and lower jaws, nose, orbits, and other facial structures.

Axial and Appendicular Skeleton

The axial skeleton supports the head, neck, back, and chest and thus forms the vertical axis of the body. It consists of the skull, vertebral column (including the sacrum and coccyx), and the thoracic cage, formed by the ribs and sternum. The…

Pathways in Calcium Homeostasis

The body regulates calcium homeostasis with two pathways; one is signaled to turn on when blood calcium levels drop below normal and one is the pathway that is signaled to turn on when blood calcium levels are elevated.

Graph Showing Relationship Between Age and Bone Mass

Bone density peaks at about 30 years of age. Women lose bone mass more rapidly than men.

Synthesis of Vitamin D

Sunlight is one source of vitamin D.

Stages in Fracture Repair

The healing of a bone fracture follows a series of progressive steps: (a) A fracture hematoma forms. (b) Internal and external calli form. (c) Cartilage of the calli is replaced by trabecular bone. (d) Remodeling occurs.

Types of Fractures

Compare healthy bone with different types of fractures: (a) closed fracture, (b) open fracture, (c) transverse fracture, (d) spiral fracture, (e) comminuted fracture, (f) impacted fracture, (g) greenstick fracture, and (h) oblique fracture.

Progression from Epiphyseal Plate to Epiphyseal Line

As a bone matures, the epiphyseal plate progresses to an epiphyseal line. (a) Epiphyseal plates are visible in a growing bone. (b) Epiphyseal lines are the remnants of epiphyseal plates in a mature bone.

Longitudinal Bone Growth

The epiphyseal plate is responsible for longitudinal bone growth.

Endochondral Ossification

Endochondral ossification follows five steps. (a) Mesenchymal cells differentiate into chondrocytes. (b) The cartilage model of the future bony skeleton and the perichondrium form. (c) Capillaries penetrate cartilage. Perichondrium transforms into…

Intramembranous Ossification

Intramembranous ossification follows four steps. (a) Mesenchymal cells group into clusters, and ossification centers form. (b) Secreted osteoid traps osteoblasts, which then become osteocytes. (c) Trabecular matrix and periosteum form. (d) Compact…

Diagram of Blood and Nerve Supply to Bone

Blood vessels and nerves enter the bone through the nutrient foramen.

Paget's Disease

Normal leg bones are relatively straight, but those affected by Paget’s disease are porous and curved.

Diagram of Spongy Bone

Spongy bone is composed of trabeculae that contain the osteocytes. Red marrow fills the spaces in some bones.

Diagram of Compact Bone

(a) This cross-sectional view of compact bone shows the basic structural unit, the osteon. (b) In this micrograph of the osteon, you can clearly see the concentric lamellae and central canals.

Bone Cells

Four types of cells are found within bone tissue. Osteogenic cells are undifferentiated and develop into osteoblasts. When osteoblasts get trapped within the calcified matrix, their structure and function changes, and they become osteocytes.…

Bone Features

The surface features of bones depend on their function, location, attachment of ligaments and tendons, or the penetration of blood vessels and nerves.

Anatomy of a Flat Bone

This cross-section of a flat bone shows the spongy bone (diploë) lined on either side by a layer of compact bone.

Periosteum and Endosteum

The periosteum forms the outer surface of bone, and the endosteum lines the medullary cavity.

Anatomy of a Long Bone

A typical long bone shows the gross anatomical characteristics of bone.

Classifications of Bones

Bones are classified according to their shape.

Bones Protect Brain

The cranium completely surrounds and protects the brain from non-traumatic injury.

Acne

Acne is a result of over-productive sebaceous glands, which leads to formation of blackheads and inflammation of the skin.

Thermoregulation

During strenuous physical activities, such as skiing (a) or running (c), the dermal blood vessels dilate and sweat secretion increases (b). These mechanisms prevent the body from overheating. In contrast, the dermal blood vessels constrict to…

Eccrine Gland

Eccrine glands are coiled glands in the dermis that release sweat that is mostly water.

Nails

The nail is an accessory structure of the integumentary system.

Hair

Hair follicles originate in the epidermis and have many different parts.

Vitiligo

Individuals with vitiligo experience depigmentation that results in lighter colored patches of skin. The condition is especially noticeable on darker skin.

Moles

Moles range from benign accumulations of melanocytes to melanomas. These structures populate the landscape of our skin.

Skin Pigmentation

The relative coloration of the skin depends of the amount of melanin produced by melanocytes in the stratum basale and taken up by keratinocytes.

Layers of the Dermis

This stained slide shows the two components of the dermis—the papillary layer and the reticular layer. Both are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat…

Cells of the Epidermis

The cells in the different layers of the epidermis originate from basal cells located in the stratum basale, yet the cells of each layer are distinctively different.

Layers of the Epidermis

The epidermis of thick skin has five layers: stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.

Layers of Skin

The skin is composed of two main layers: the epidermis, made of closely packed epithelial cells, and the dermis, made of dense, irregular connective tissue that houses blood vessels, hair follicles, sweat glands, and other structures. Beneath the…

Nervous Tissue

Nervous tissue is made up of neurons and neuroglia. The cells of nervous tissue are specialized to transmit and receive impulses

The Neuron

The cell body of a neuron, also called the soma, contains the nucleus and mitochondria. The dendrites transfer the nerve impulse to the soma. The axon carries the action potential away to another excitable cell.

Types of Cartilage

Cartilage is a connective tissue consisting of collagenous fibers embedded in a firm matrix of chondroitin sulfates. (a) Hyaline cartilage provides support with some flexibility. The example is from dog tissue. (b) Fibrocartilage provides some…

Dense Connective Tissue

(a) Dense regular connective tissue consists of collagenous fibers packed into parallel bundles. (b) Dense irregular connective tissue consists of collagenous fibers interwoven into a mesh-like network. From top,

Reticular Tissue

This is a loose connective tissue made up of a network of reticular fibers that provides a supportive framework for soft organs.

Adipose Tissue

This is a loose connective tissue that consists of fat cells with little extracellular matrix. It stores fat for energy and provides insulation.

Connective Tissue Proper

Fibroblasts produce this fibrous tissue. Connective tissue proper includes the fixed cells fibrocytes, adipocytes, and mesenchymal cells.

Sebaceous Glands

These glands secrete oils that lubricate and protect the skin. They are holocrine glands and they are destroyed after releasing their contents. New glandular cells form to replace the cells that are lost

Modes of Glandular Secretion

(a) In merocrine secretion, the cell remains intact. (b) In apocrine secretion, the apical portion of the cell is released, as well. (c) In holocrine secretion, the cell is destroyed as it releases its product and the cell itself becomes part of the…

Types of Exocrine Glands

Exocrine glands are classified by their structure.

Summary of Epithelial Tissue Cells

A stratified epithelium consists of several stacked layers of cells. This epithelium protects against physical and chemical wear and tear. The stratified epithelium is named by the shape of the most apical layer of cells, closest to the free space.…

Goblet Cell

(a) In the lining of the small intestine, columnar epithelium cells are interspersed with goblet cells. (b) The arrows in this micrograph point to the mucous-secreting goblet cells.

Cells of Epithelial Tissue

Simple epithelial tissue is organized as a single layer of cells and stratified epithelial tissue is formed by several layers of cells.

Types of Cell Junctions

The three basic types of cell-to-cell junctions are tight junctions, gap junctions, and anchoring junctions.

Tissue Membranes

The two broad categories of tissue membranes in the body are (1) connective tissue membranes, which include synovial membranes, and (2) epithelial membranes, which include mucous membranes, serous membranes, and the cutaneous membrane, in other…

Embryonic Origin of Tissues

The zygote, or fertilized egg, is a single cell formed by the fusion of an egg and sperm. After fertilization the zygote gives rise to rapid mitotic cycles, generating many cells to form the embryo. The first embryonic cells generated have the…

Four Types of Tissue: Body

The four types of tissues are exemplified in nervous tissue, stratified squamous epithelial tissue, cardiac muscle tissue, and connective tissue in small intestine. Clockwise from nervous tissue

Micrograph of Cervical Tissue

This figure is a view of the regular architecture of normal tissue contrasted with the irregular arrangement of cancerous cells.

Stem Cells

The capacity of stem cells to differentiate into specialized cells make them potentially valuable in therapeutic applications designed to replace damaged cells of different body tissues.

Hematopoiesis

The process of hematopoiesis involves the differentiation of multipotent cells into blood and immune cells. The multipotent hematopoietic stem cells give rise to many different cell types, including the cells of the immune system and red blood cells.

Cell Division: Mitosis

The stages of cell division oversee the separation of identical genetic material into two new nuclei, followed by the division of the cytoplasm.

A Homologous Pair of Chromosomes with their Attached Sister Chromatids

The red and blue colors correspond to a homologous pair of chromosomes. Each member of the pair was separately inherited from one parent. Each chromosome in the homologous pair is also bound to an identical sister chromatid, which is produced by DNA…

From DNA to Protein: Transcription through Translation

Transcription within the cell nucleus produces an mRNA molecule, which is modified and then sent into the cytoplasm for translation. The transcript is decoded into a protein with the help of a ribosome and tRNA molecules.

Translation from RNA to Protein

During translation, the mRNA transcript is “read” by a functional complex consisting of the ribosome and tRNA molecules. tRNAs bring the appropriate amino acids in sequence to the growing polypeptide chain by matching their anti-codons with…

Splicing DNA

In the nucleus, a structure called a spliceosome cuts out introns (noncoding regions) within a pre-mRNA transcript and reconnects the exons.

Transcription: from DNA to mRNA

In the first of the two stages of making protein from DNA, a gene on the DNA molecule is transcribed into a complementary mRNA molecule.

The Genetic Code

DNA holds all of the genetic information necessary to build a cell’s proteins. The nucleotide sequence of a gene is ultimately translated into an amino acid sequence of the gene’s corresponding protein.

DNA Replication

DNA replication faithfully duplicates the entire genome of the cell. During DNA replication, a number of different enzymes work together to pull apart the two strands so each strand can be used as a template to synthesize new complementary strands.…

Molecular Structure of DNA

The DNA double helix is composed of two complementary strands. The strands are bonded together via their nitrogenous base pairs using hydrogen bonds.

DNA Macrostructure

Strands of DNA are wrapped around supporting histones. These proteins are increasingly bundled and condensed into chromatin, which is packed tightly into chromosomes when the cell is ready to divide.

Multinucleate Muscle Cell

Unlike cardiac muscle cells and smooth muscle cells, which have a single nucleus, a skeletal muscle cell contains many nuclei, and is referred to as “multinucleated.” These muscle cells are long and fibrous (often referred to as muscle fibers).…

The Nucleus

The nucleus is the control center of the cell. The nucleus of living cells contains the genetic material that determines the entire structure and function of that cell.

The Three Components of the Cytoskeleton

The cytoskeleton consists of (a) microtubules, (b) microfilaments, and (c) intermediate filaments. The cytoskeleton plays an important role in maintaining cell shape and structure, promoting cellular movement, and aiding cell division.

Mitochondrion

The mitochondria are the energy-conversion factories of the cell. (a) A mitochondrion is composed of two separate lipid bilayer membranes. Along the inner membrane are various molecules that work together to produce ATP, the cell’s major energy…

Golgi Apparatus

(a) The Golgi apparatus manipulates products from the rough ER, and also produces new organelles called lysosomes. Proteins and other products of the ER are sent to the Golgi apparatus, which organizes, modifies, packages, and tags them. Some of…

Endoplasmic Reticulum (ER)

(a) The ER is a winding network of thin membranous sacs found in close association with the cell nucleus. The smooth and rough endoplasmic reticula are very different in appearance and function (source: mouse tissue). (b) Rough ER is studded with…

Prototypical Human Cell

While this image is not indicative of any one particular human cell, it is a prototypical example of a cell containing the primary organelles and internal structures.

Fatty Acid Shapes

The level of saturation of a fatty acid affects its shape. (a) Saturated fatty acid chains are straight. (b) Unsaturated fatty acid chains are kinked.

Exocytosis

Exocytosis is much like endocytosis in reverse. Material destined for export is packaged into a vesicle inside the cell. The membrane of the vesicle fuses with the cell membrane, and the contents are released into the extracellular space.

Three Forms of Endocytosis

Endocytosis is a form of active transport in which a cell envelopes extracellular materials using its cell membrane. (a) In phagocytosis, which is relatively nonselective, the cell takes in a large particle. (b) In pinocytosis, the cell takes in…

Sodium-Potassium Pump

The sodium-potassium pump is found in many cell (plasma) membranes. Powered by ATP, the pump moves sodium and potassium ions in opposite directions, each against its concentration gradient. In a single cycle of the pump, three sodium ions are…

Facilitated Diffusion

(a) Facilitated diffusion of substances crossing the cell (plasma) membrane takes place with the help of proteins such as channel proteins and carrier proteins. Channel proteins are less selective than carrier proteins, and usually mildly…

Simple Diffusion across the Cell (Plasma) Membrane

The structure of the lipid bilayer allows small, uncharged substances such as oxygen and carbon dioxide, and hydrophobic molecules such as lipids, to pass through the cell membrane, down their concentration gradient, by simple diffusion.

Cell Membrane

The cell membrane of the cell is a phospholipid bilayer containing many different molecular components, including proteins and cholesterol, some with carbohydrate groups attached.

Fluorescence-stained Cell Undergoing Mitosis

A lung cell from a newt, commonly studied for its similarity to human lung cells, is stained with fluorescent dyes. The green stain reveals mitotic spindles, red is the cell membrane and part of the cytoplasm, and the structures that appear light…

Adenosine Triphosphate

The nucleotide adenosine triphosphate (ATP), is composed of a ribose sugar, an adenine base, and three phosphate groups ([link]). ATP is classified as a high energy compound because the two covalent bonds linking its three phosphates store a…

Elements of the Human Body

The main elements that compose the human body are shown from most abundant to least abundant.

Medical Imaging Techniques

(a) The results of a CT scan of the head are shown as successive transverse sections. (b) An MRI machine generates a magnetic field around a patient. (c) PET scans use radiopharmaceuticals to create images of active blood flow and physiologic…

X-Ray of a Hand

High energy electromagnetic radiation allows the internal structures of the body, such as bones, to be seen in X-rays like these

Literature Reviews for Education and Nursing Graduate Students

Literature Reviews for Education and Nursing Graduate Students is an open textbook designed for students in graduate-level nursing and education programs. Its intent is to recognize the significant role the literature review plays in the research…

Human Anatomy and Physiology Preparatory Course

The overall purpose of this preparatory course textbook is to help students familiarize with some terms and some basic concepts they will find later in the Human Anatomy and Physiology I course. The organization and functioning of the human organism…

Health and Safety in Canadian Workplaces

Workplace injuries happen every day and can profoundly affect workers, their families, and the communities they live in. This textbook provides workers with an introduction to effective injury prevention. The book pays particular attention to how…

Creative Clinical Teaching In The Health Professions

This peer reviewed e-book is a must-read for nurses and other health professionals who strive to teach with creativity and excellence in clinical settings. Each chapter presents current evidence informed educational practice knowledge. Each topic is…

Serous Membrane

A serous membrane (also referred to a serosa) is one of the thin membranes that cover the walls and organs in the thoracic and abdominopelvic cavities. The parietal layers of the membranes line the walls of the body cavity (pariet- refers to a cavity…

Regions and Quadrants of the Peritoneal Cavity

The more detailed regional approach subdivides the cavity with one horizontal line immediately inferior to the ribs and one immediately superior to the pelvis, and two vertical lines drawn as if dropped from the midpoint of each clavicle…

Dorsal and Ventral Body Cavities

The posterior (dorsal) and anterior (ventral) cavities are each subdivided into smaller cavities. In the posterior (dorsal) cavity, the cranial cavity houses the brain, and the spinal cavity (or vertebral cavity) encloses the spinal cord. Just as the…

Positive Feedback Loop

Normal childbirth is driven by a positive feedback loop. A positive feedback loop results in a change in the body’s status, rather than a return to homeostasis.

Organ Systems of the Human Body

Levels of Structural Organization of the Human Body

Before you begin to study the different structures and functions of the human body, it is helpful to consider its basic architecture; that is, how its smallest parts are assembled into larger structures. It is convenient to consider the structures of…

Shoulder Joint

The shoulder joint is called the glenohumeral joint. This is a ball-and-socket joint formed by the articulation between the head of the humerus and the glenoid cavity of the scapula ([link]). This joint has the largest range of motion of any joint in…

Dublin Core

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